{"id":"W2418561090","doi":"10.1186/s12885-016-2385-z","title":"HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Trastuzumab; Pertuzumab; Anthracycline; Internal medicine; Oncology; Metastatic breast cancer; Breast cancer; Vinorelbine; Cardiotoxicity; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002770001,0.002761381,0.00217843,0.000578584,0.00040943,0.001287386,0.00143822,0.002223066,0.00832349],"category_scores_gemma":[0.001975396,0.0009544757,0.001854611,0.0003678316,0.001762262,0.001629915,0.0005875197,0.003408594,0.001271551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001124546,"about_ca_system_score_gemma":0.001662625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006793354,"about_ca_topic_score_gemma":0.001658776,"domain_scores_codex":[0.9993029,0.0003503845,0.00003067383,0.0001509966,0.00004183166,0.0001232637],"domain_scores_gemma":[0.9991305,0.0001817619,0.0002098919,0.00006856524,0.00004437908,0.0003647971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9689288,0.01398004,0.0007386286,0.000461343,0.0004347169,0.00008206229,0.000080973,0.0006036537,0.004145912,0.0003368633,0.001415373,0.008791422],"study_design_scores_gemma":[0.9216459,0.07526135,0.0009737008,0.00002725307,0.0001724158,0.00003610122,0.00002226782,0.000309441,0.0003660038,0.0001816115,0.0009893334,0.00001464115],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737278,0.002611426,0.0008127171,0.001393842,0.001145417,0.01350551,0.001683452,0.0001814829,0.004938385],"genre_scores_gemma":[0.9561661,0.001954147,0.003144359,0.003663328,0.001167206,0.01947616,0.003018801,0.00004452942,0.01136542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00832349,"threshold_uncertainty_score":0.02784485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509831432039076,"score_gpt":0.3684742946253877,"score_spread":0.3433759803049969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}