{"id":"W2418561090","doi":"10.1186/s12885-016-2385-z","title":"HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician’s choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Trastuzumab; Pertuzumab; Anthracycline; Internal medicine; Oncology; Metastatic breast cancer; Breast cancer; Vinorelbine; Cardiotoxicity; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000632346,0.0006691937,0.002792123,0.0003804949,0.00006562121,0.00001879589,0.0002945768,0.0001724695,0.0008218769],"category_scores_gemma":[0.0002807945,0.0004401036,0.0004483113,0.001021253,0.0008663177,0.0003285785,0.00005367285,0.0003884138,0.000007657238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002942145,"about_ca_system_score_gemma":0.003697813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005107218,"about_ca_topic_score_gemma":0.003205416,"domain_scores_codex":[0.9945405,0.0005353856,0.001488028,0.0009428047,0.001543071,0.0009502486],"domain_scores_gemma":[0.995945,0.001202826,0.0008942185,0.0007646115,0.0008530853,0.0003402121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8621294,0.003186422,0.003763879,0.0006748433,0.0007900001,0.00002522116,0.000589327,0.0003809981,0.001370118,0.000005875673,0.0002638555,0.12682],"study_design_scores_gemma":[0.96618,0.005540583,0.01469562,0.00474198,0.0006119825,0.000006532166,0.0001197974,0.0004773036,0.006874633,0.000008982853,0.0002329314,0.0005096605],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987031,0.001478222,0.0006903572,0.0005080602,0.0004254388,0.008360045,0.001070206,0.00005898988,0.0003776391],"genre_scores_gemma":[0.9930308,0.002733756,0.0004414088,0.0001693389,0.0003762707,0.002389338,0.00005759808,0.0001780608,0.0006234335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1263103,"threshold_uncertainty_score":0.9998051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509831432039076,"score_gpt":0.3684742946253877,"score_spread":0.3433759803049969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}