{"id":"W2418695111","doi":"10.2741/4399","title":"DNA methylation at enhancer regions Novel avenues for epigenetic biomarker development","year":2015,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute; Cancer Research Institute","keywords":"DNA methylation; Epigenetics; Enhancer; Methylation; Biomarker; Computational biology; Biology; Epigenomics; Biomarker discovery; Genetics; Gene; Gene expression; Proteomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000887616,0.0003360814,0.0005990599,0.0002542845,0.0001502271,0.00003537523,0.0004393176,0.0004267757,0.000002388838],"category_scores_gemma":[0.0002254025,0.0003076471,0.0001872264,0.0004006441,0.0001687628,0.00000632891,0.0001930628,0.00008607453,0.000006426741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745404,"about_ca_system_score_gemma":0.000611108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002878848,"about_ca_topic_score_gemma":0.00002873886,"domain_scores_codex":[0.9978963,0.00008838608,0.0005617771,0.000794668,0.0002561157,0.0004027556],"domain_scores_gemma":[0.9989244,0.00002509295,0.00035199,0.0004460009,0.0001257825,0.0001267004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001805201,0.00006676352,0.00006322803,0.0008580586,0.0000494577,6.00765e-7,0.00008292884,0.00001181357,0.01692903,0.00001110636,0.003636661,0.9782723],"study_design_scores_gemma":[0.0002119642,0.00006327571,0.00006116636,0.0004899395,0.00005958341,0.000001448982,0.000009802513,0.00005031349,0.01406384,0.0001133746,0.9844839,0.0003913754],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002969693,0.8728661,0.1245414,0.00001313047,0.00124295,0.0008224642,0.00006773631,0.000007914754,0.0001412935],"genre_scores_gemma":[0.0001670524,0.9541095,0.04324205,0.00001655501,0.0001369938,0.0003115409,0.0005644549,0.00004453521,0.001407268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9808472,"threshold_uncertainty_score":0.9999375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08923732628231601,"score_gpt":0.3591994757726861,"score_spread":0.2699621494903701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}