{"id":"W2418695111","doi":"10.2741/4399","title":"DNA methylation at enhancer regions Novel avenues for epigenetic biomarker development","year":2015,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute; Cancer Research Institute","keywords":"DNA methylation; Epigenetics; Enhancer; Methylation; Biomarker; Computational biology; Biology; Epigenomics; Biomarker discovery; Genetics; Gene; Gene expression; Proteomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008967372,0.0006332211,0.001009001,0.001444162,0.0002720169,0.0008215311,0.0009052081,0.001260946,0.003320117],"category_scores_gemma":[0.0009021414,0.0002958002,0.0005204032,0.0009951841,0.0008758552,0.001586476,0.0007012769,0.001999553,0.00159261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008673808,"about_ca_system_score_gemma":0.001032442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006734947,"about_ca_topic_score_gemma":0.001299576,"domain_scores_codex":[0.99979,0.0000516594,0.0000222656,0.00005359661,0.00006191553,0.00002063435],"domain_scores_gemma":[0.999671,0.0001731604,0.00004459647,0.00001547311,0.00006756992,0.00002824063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008413914,0.00004856827,0.0007193814,0.01344976,0.0001090056,0.0005845878,0.0001356057,0.00100841,0.02003487,0.02790731,0.01678934,0.9191291],"study_design_scores_gemma":[0.00001461693,0.00008582028,0.000997138,0.001696151,0.00008541789,0.002118053,0.00006454041,0.0002741824,0.007874448,0.008400597,0.9783596,0.00002947656],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003458196,0.994663,0.001716384,0.001000006,0.0002996549,0.000009955163,0.00003803444,0.00001973485,0.001907355],"genre_scores_gemma":[0.004849419,0.9911623,0.001371948,0.0005321369,0.0002992905,0.00001819759,0.00007112678,0.000005146661,0.001690465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003320117,"threshold_uncertainty_score":0.01110691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08923732628231601,"score_gpt":0.3591994757726861,"score_spread":0.2699621494903701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}