{"id":"W2418711588","doi":"10.1016/j.jconrel.2016.06.019","title":"Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response","year":2016,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Canada Research Chairs; University of Toronto; University of Waterloo","funders":"","keywords":"Epitope; CTL*; Cytotoxic T cell; Chemistry; Peptide; CD8; Virology; Immune system; Antigen; Biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008117924,0.0002223602,0.0001290501,0.0001026726,0.0001323621,0.0001565663,0.0001360468,0.0002690361,0.001728381],"category_scores_gemma":[0.00007051281,0.0001024732,0.0001406798,0.0000816751,0.0000770961,0.0001373037,0.0001479328,0.0004887496,0.0004839731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388122,"about_ca_system_score_gemma":0.0001050977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001303532,"about_ca_topic_score_gemma":0.00025727,"domain_scores_codex":[0.9999235,0.00001168415,0.000006250116,0.00001605356,0.00001965784,0.00002295916],"domain_scores_gemma":[0.9999675,0.000005998979,0.000007724006,0.000003919117,0.000005043925,0.000009877439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000487853,0.00003140778,0.0000208934,0.0000182341,0.000001914309,0.00002898038,0.000006044802,0.00006742047,0.9989982,0.00004729565,0.00003343551,0.0006973043],"study_design_scores_gemma":[0.00002713151,0.0002199368,0.0003636571,0.000002646826,0.000009515012,0.0001132743,0.000006680794,0.0008348381,0.996901,0.0000216582,0.001496443,0.000003333559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928445,0.0007164962,0.004347554,0.00008066119,0.0001035025,0.00006959678,0.0001364441,0.00008172789,0.001619519],"genre_scores_gemma":[0.9914972,0.0002901985,0.005220322,0.00007075848,0.00002111732,0.00005686487,0.0002429558,0.0000201191,0.002580404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728381,"threshold_uncertainty_score":0.005782008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828863239012735,"score_gpt":0.2316245918266339,"score_spread":0.2233359594365066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}