{"id":"W2418711588","doi":"10.1016/j.jconrel.2016.06.019","title":"Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response","year":2016,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Canada Research Chairs; University of Toronto; University of Waterloo","funders":"","keywords":"Epitope; CTL*; Cytotoxic T cell; Chemistry; Peptide; CD8; Virology; Immune system; Antigen; Biology; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001102339,0.0002557136,0.000890353,0.0004133058,0.0001950326,0.00002510615,0.0001656151,0.0002389666,0.00006704483],"category_scores_gemma":[0.000324846,0.0001809168,0.0002687178,0.00008877119,0.0001324657,0.0002376054,0.00003980779,0.0001652206,0.00001361763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001649612,"about_ca_system_score_gemma":0.0005370597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008334723,"about_ca_topic_score_gemma":0.000001216343,"domain_scores_codex":[0.9975147,0.00073418,0.001112678,0.0002201046,0.0001173159,0.0003010655],"domain_scores_gemma":[0.996201,0.002112116,0.0009635641,0.0001978298,0.0004471749,0.0000782974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1888264,0.000211838,0.00003438172,0.00005882367,0.0005098423,0.000007273325,0.0003719868,0.00001341687,0.8065142,0.00001360758,0.0005929882,0.002845234],"study_design_scores_gemma":[0.03859739,0.002297816,0.001194595,0.0003059679,0.0002254704,0.0002089865,0.0003245163,0.0000254005,0.9480855,0.00001831577,0.008510856,0.0002051803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798388,0.01664205,0.001472939,0.0005568307,0.0006483331,0.0007445471,0.00007181138,0.00001174667,0.00001288702],"genre_scores_gemma":[0.993234,0.003815222,0.00134624,0.0001756958,0.00005869653,0.00002895622,0.000005301434,0.00002732606,0.001308545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.150229,"threshold_uncertainty_score":0.7377575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828863239012735,"score_gpt":0.2316245918266339,"score_spread":0.2233359594365066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}