{"id":"W2418726853","doi":"10.1385/1-59259-141-8:389","title":"Construction of First-Generation Adenoviral Vectors","year":2003,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Recombinant DNA; Biology; Genome; Titer; Gene; Virology; Vector (molecular biology); Viral vector; Transfection; DNA; Virus; Genetic enhancement; Computational biology; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422686,0.00009822744,0.00009407194,0.00003934182,0.00008428207,0.00001497811,0.0001105093,0.00009333628,0.00003891647],"category_scores_gemma":[0.00002970929,0.000100675,0.00005712038,0.00001291371,0.0001273037,0.000002107076,0.00002686569,0.00006161766,0.000002038449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001057686,"about_ca_system_score_gemma":0.00003931788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003121515,"about_ca_topic_score_gemma":0.0002596431,"domain_scores_codex":[0.9992264,0.00009815236,0.0001591885,0.0002125905,0.0001414829,0.0001621925],"domain_scores_gemma":[0.9995061,0.000004621869,0.00006354019,0.000303977,0.00007890547,0.00004285774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002964881,0.00003815977,0.0002179835,0.00003165345,0.00008679802,0.000001482515,0.0001169808,0.0001457893,0.9838033,0.004754786,0.0009878868,0.009518687],"study_design_scores_gemma":[0.0004173086,0.0006698656,0.00003818016,0.000004411596,0.000009443402,0.0000046401,0.00001576806,0.00004415193,0.9614293,0.00007753468,0.03718485,0.0001045706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820658,0.001734123,0.0002897432,0.000005279624,0.0001447003,0.0001977177,0.000008525999,0.00001104997,0.01554307],"genre_scores_gemma":[0.9980007,0.0001175007,0.0002850798,0.00002475408,0.0001510852,0.00002669587,0.00003044202,0.00001878054,0.001344931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03619696,"threshold_uncertainty_score":0.4105409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0528626228275314,"score_gpt":0.2938918215696913,"score_spread":0.2410291987421599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}