{"id":"W2418955755","doi":"10.1038/sj.onc.1203516","title":"GA-binding protein α/β is a critical regulator of the BRCA1 promoter","year":2000,"lang":"en","type":"article","venue":"Oncogene","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Cancer Care Ontario; McKnight Foundation","keywords":"Transactivation; Biology; Transcription factor; Promoter; Molecular biology; Regulator; Activator (genetics); Binding site; Transcription (linguistics); Cancer research; Cell culture; Mutant; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007584551,0.00009314525,0.00008898963,0.00001155547,0.00004303112,0.000008231965,0.0001525387,0.00008798909,0.0003337647],"category_scores_gemma":[0.00003256136,0.00007145993,0.00008994398,0.00006631589,0.00005952752,0.00000131629,0.00004914556,0.00005102837,0.00001520822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000510904,"about_ca_system_score_gemma":0.00003316409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004604638,"about_ca_topic_score_gemma":0.000003532119,"domain_scores_codex":[0.9993733,0.00001970778,0.0001396063,0.0001875759,0.0001089953,0.0001708824],"domain_scores_gemma":[0.9995606,0.000003339807,0.00001803845,0.000341227,0.00003036971,0.00004644993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001489272,0.00002799512,0.0001336862,0.0000231086,0.00001534915,8.328068e-7,0.00003407038,0.000021117,0.9942057,0.00002929215,0.0004909262,0.005003103],"study_design_scores_gemma":[0.0001743897,0.00007799811,0.0003616073,0.00003046301,0.00001165047,0.00001536122,0.00001019635,0.00006363817,0.9686494,0.00002919398,0.03048213,0.00009390811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963236,0.0003305145,0.0003524661,0.0004037824,0.00004925716,0.0001721493,0.00001688986,0.000006513367,0.002344832],"genre_scores_gemma":[0.9925082,0.0000154467,0.001272719,0.00008739248,0.0001423331,0.00001640394,0.000004851344,0.0000172822,0.005935393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02999121,"threshold_uncertainty_score":0.365449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006516270823253918,"score_gpt":0.2855528991365331,"score_spread":0.2790366283132792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}