{"id":"W2418955755","doi":"10.1038/sj.onc.1203516","title":"GA-binding protein α/β is a critical regulator of the BRCA1 promoter","year":2000,"lang":"en","type":"article","venue":"Oncogene","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Cancer Care Ontario; McKnight Foundation","keywords":"Transactivation; Biology; Transcription factor; Promoter; Molecular biology; Regulator; Activator (genetics); Binding site; Transcription (linguistics); Cancer research; Cell culture; Mutant; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430584,0.0006405471,0.0003478356,0.0003906446,0.0003224965,0.0004509129,0.0004375331,0.000407495,0.001624041],"category_scores_gemma":[0.0002410475,0.0003607608,0.0002552854,0.0001611639,0.0003983902,0.0002356226,0.000393296,0.001370735,0.001442311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008216285,"about_ca_system_score_gemma":0.0005101906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001762584,"about_ca_topic_score_gemma":0.001945637,"domain_scores_codex":[0.9998412,0.00002148572,0.00000957931,0.0000529295,0.000039916,0.00003482731],"domain_scores_gemma":[0.9997882,0.00003593272,0.00004788364,0.00002176589,0.0000201401,0.00008603478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004904159,0.000004621766,0.00007818974,0.00001366995,0.000001891366,0.00005640294,0.000005858317,0.0000533342,0.9987546,0.0002064529,0.0001010309,0.0006749679],"study_design_scores_gemma":[0.00001315589,0.00002434501,0.00294952,0.000014342,0.00001013203,0.0004902309,0.00002525156,0.00155253,0.9890725,0.0002576649,0.005580606,0.000009609415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447872,0.004928104,0.03949386,0.001086442,0.000336025,0.00007836983,0.002032764,0.001347963,0.005909181],"genre_scores_gemma":[0.9821514,0.001018252,0.008867773,0.000261032,0.00002566261,0.00004456494,0.001529459,0.0002641442,0.005837836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762584,"threshold_uncertainty_score":0.005961418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006516270823253918,"score_gpt":0.2855528991365331,"score_spread":0.2790366283132792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}