{"id":"W2419250658","doi":"10.1124/dmd.116.070052","title":"Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Endocrinology; Internal medicine; CYP3A; Cytochrome P450; Parathyroid hormone; Microsome; Metabolism; Chemistry; Biology; Medicine; Enzyme; Calcium; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003197409,0.0007834933,0.0008026157,0.0006328144,0.0005498884,0.000317831,0.0003847244,0.000637412,0.00186694],"category_scores_gemma":[0.0005405657,0.0003912236,0.0007087063,0.0004050018,0.001159425,0.0008224475,0.0002954176,0.001530353,0.0002844954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000551597,"about_ca_system_score_gemma":0.0007539503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004559302,"about_ca_topic_score_gemma":0.005586485,"domain_scores_codex":[0.9998186,0.00002596027,0.00001203506,0.00003336202,0.00002840084,0.00008173076],"domain_scores_gemma":[0.9992347,0.0001934845,0.0001409841,0.0001244804,0.00007940795,0.0002268692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2253705,0.008309166,0.0162316,0.0003833487,0.0004070041,0.001908797,0.0004909552,0.002461899,0.7129008,0.0005965709,0.0008666019,0.03007278],"study_design_scores_gemma":[0.002430602,0.06993344,0.06703316,0.00004068974,0.0006184693,0.0009753793,0.0005974842,0.004370919,0.8508973,0.0007101854,0.002286611,0.0001058328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984988,0.0005398918,0.0002686007,0.00008306431,0.00003156186,0.00002049348,0.0002335582,0.00002302935,0.0003010228],"genre_scores_gemma":[0.9968899,0.0006507055,0.000289635,0.00006611894,0.00003651985,0.00002591313,0.0003433755,0.00001353153,0.001684337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004559302,"threshold_uncertainty_score":0.009065568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00553208938779862,"score_gpt":0.2585689702395638,"score_spread":0.2530368808517652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}