{"id":"W2419364291","doi":"10.1055/s-2003-43054","title":"Cholesterol, a Modulator of Membrane-associated Aβ-fibrillogenesis","year":2003,"lang":"en","type":"article","venue":"Pharmacopsychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hospital for Sick Children","keywords":"Fibrillogenesis; Chemistry; Biophysics; Senile plaques; Lipid bilayer; Membrane fluidity; Fluorescence anisotropy; Membrane; Fibril; Bilayer; Amyloid (mycology); Peptide; Diphenylhexatriene; Fluorescence microscope; Biochemistry; Fluorescence; Alzheimer's disease; Biology; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000930844,0.0001611155,0.0001488175,0.0002991653,0.0002784039,0.000296264,0.00009833252,0.0001746855,0.0002703698],"category_scores_gemma":[0.0002198605,0.00007892288,0.00007138674,0.000159694,0.0001917351,0.0001782948,0.0001418478,0.0001601727,0.0001000075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002803328,"about_ca_system_score_gemma":0.0001983903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482843,"about_ca_topic_score_gemma":0.001232552,"domain_scores_codex":[0.9999427,0.00001480569,0.000004204017,0.000009611607,0.00001446421,0.00001432771],"domain_scores_gemma":[0.9999249,0.00001944835,0.00001782843,0.000006185232,0.00001702951,0.00001453783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218418,0.00003262546,0.001614031,0.0001043306,0.000009326854,0.0004357583,0.00006330898,0.00006827254,0.9896551,0.0005488954,0.0001173286,0.007132665],"study_design_scores_gemma":[0.00003434384,0.000345168,0.03464072,0.00003105312,0.00004358081,0.00142474,0.0001491086,0.0009034491,0.9547083,0.001040362,0.006668005,0.00001119183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798763,0.01458469,0.001755036,0.0002024811,0.00003815632,0.00003023813,0.0001150378,0.00004498221,0.003353158],"genre_scores_gemma":[0.9909914,0.007422889,0.0007038135,0.00003265182,0.0000233298,0.0000122934,0.0000509924,0.000003589253,0.0007590986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482843,"threshold_uncertainty_score":0.002948403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02673518190996225,"score_gpt":0.3301261226088121,"score_spread":0.3033909406988499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}