{"id":"W2419464122","doi":"10.1136/annrheumdis-2015-eular.3172","title":"OP0200 Global DNA Methylation Patterns Differ Between Responders and Non-Responders in Psoriatic Arthritis Patients Treated with Tumor Necrosis Factor-α Inhibitors","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Medicine; Psoriatic arthritis; Etanercept; CpG site; Internal medicine; DNA methylation; Oncology; Tumor necrosis factor alpha; Methylation; Arthritis; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261159,0.000119136,0.0002787997,0.0003492344,0.0001497583,0.0003073341,0.0001177219,0.0002201315,0.002379094],"category_scores_gemma":[0.0005394149,0.0001149459,0.0002421594,0.000337412,0.0001028819,0.0001378969,0.0001295503,0.0002938641,0.0002931894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002206,"about_ca_system_score_gemma":0.00009479686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214961,"about_ca_topic_score_gemma":0.001761116,"domain_scores_codex":[0.9998591,0.0000351242,0.00001290859,0.00003039601,0.00002904986,0.00003340859],"domain_scores_gemma":[0.9997873,0.00006545193,0.00006913392,0.000012338,0.000029021,0.00003687986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01246653,0.0002453044,0.8637017,0.0001899253,0.0005619178,0.0005257095,0.0006742902,0.0002395947,0.06700265,0.0000877949,0.0007863549,0.05351827],"study_design_scores_gemma":[0.00005805994,0.0006170673,0.9953365,0.000009401612,0.0001964675,0.0006117419,0.0003755844,0.0002737938,0.001711974,0.00008140846,0.0007208752,0.000007379952],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983663,0.000575481,0.00009442997,0.00004664491,0.000006606577,0.000006071318,0.0002550181,0.000005511396,0.0006438143],"genre_scores_gemma":[0.9990269,0.0001288261,0.00005424874,0.00004155807,0.000006775536,0.000007547456,0.0002048093,0.000002949311,0.0005263496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379094,"threshold_uncertainty_score":0.007958829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02556729447333575,"score_gpt":0.2778202234069096,"score_spread":0.2522529289335739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}