{"id":"W2419513064","doi":"10.1097/qad.0000000000000729","title":"Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity","year":2015,"lang":"en","type":"article","venue":"AIDS","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Montreal General Hospital; Jewish General Hospital; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Granzyme B; Perforin; Granzyme; Interleukin 21; Lymphokine-activated killer cell; Immunology; Interleukin 12; Antibody; Natural killer cell; Population; Cytotoxic T cell; Biology; Chemistry; Immune system; T cell; Monoclonal antibody; Medicine; CD8; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150979,0.0001943617,0.0002846824,0.00007867663,0.00008000732,0.0003565637,0.0001929162,0.0002405422,0.002712017],"category_scores_gemma":[0.0004619538,0.00009886656,0.0001329982,0.00006993496,0.0002231841,0.000216327,0.0003009459,0.000503387,0.0004116363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316155,"about_ca_system_score_gemma":0.000145799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599962,"about_ca_topic_score_gemma":0.000258142,"domain_scores_codex":[0.9997187,0.00007080565,0.00003324036,0.00004423474,0.0000612481,0.00007166148],"domain_scores_gemma":[0.9997193,0.0001052763,0.00005708197,0.00004339392,0.00003404067,0.00004086575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008260428,0.0001850831,0.001533196,0.00004794816,0.000009254135,0.00004430583,0.00003336298,0.00009583749,0.9935244,0.00004773436,0.00003280872,0.003619885],"study_design_scores_gemma":[0.0001194552,0.00364008,0.01398527,0.000009182479,0.00003086042,0.0004928451,0.00005016785,0.0006665577,0.9793758,0.00005562668,0.001569413,0.000004843687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988952,0.0002125778,0.0003662363,0.00001941174,0.000005600854,0.000009900516,0.00003933306,0.00001048257,0.0004413289],"genre_scores_gemma":[0.998795,0.00008957058,0.0003817246,0.00002480201,0.000004270391,0.00001477945,0.0001074244,0.000004875177,0.0005774311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002712017,"threshold_uncertainty_score":0.009072602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007327303449486103,"score_gpt":0.2364154659782713,"score_spread":0.2290881625287852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}