{"id":"W2419513064","doi":"10.1097/qad.0000000000000729","title":"Natural killer cell education does not affect the magnitude of granzyme B delivery to target cells by antibody-dependent cellular cytotoxicity","year":2015,"lang":"en","type":"article","venue":"AIDS","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Montreal General Hospital; Jewish General Hospital; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Antibody-dependent cell-mediated cytotoxicity; Granzyme B; Perforin; Granzyme; Interleukin 21; Lymphokine-activated killer cell; Immunology; Interleukin 12; Antibody; Natural killer cell; Population; Cytotoxic T cell; Biology; Chemistry; Immune system; T cell; Monoclonal antibody; Medicine; CD8; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003349349,0.0001772855,0.0002138257,0.00009634095,0.0001201818,0.00002006013,0.0002411223,0.0001523524,0.0008738705],"category_scores_gemma":[0.00004455811,0.0001116531,0.0001143835,0.00011912,0.00007991709,0.0001427095,0.00008531884,0.000312783,0.00102214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006480335,"about_ca_system_score_gemma":0.00008211794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005810995,"about_ca_topic_score_gemma":0.000006604806,"domain_scores_codex":[0.9988779,0.0002919938,0.0002706449,0.0002464662,0.00007658067,0.0002363908],"domain_scores_gemma":[0.9992511,0.0000877881,0.0001329478,0.0003136184,0.0001804799,0.00003409873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002425725,0.0002554332,0.0005286777,0.00001276619,0.0000460076,6.518973e-7,0.0003893587,0.000009830029,0.9225289,0.00004474412,0.07559421,0.0003468251],"study_design_scores_gemma":[0.0005082025,0.0003193017,0.0005665428,0.00001020187,0.00003487053,0.000008393807,0.0006518129,0.000004709538,0.9115117,0.00001952171,0.08622209,0.0001427028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981939,0.001975312,0.0003954915,0.0002629229,0.01293184,0.0003638611,0.00001296216,0.00004048931,0.002078165],"genre_scores_gemma":[0.9387847,0.00004694926,0.0001236432,0.0008695183,0.00005721862,0.00001887868,0.0002157899,0.00001545754,0.05986781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05778965,"threshold_uncertainty_score":0.9997557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007327303449486103,"score_gpt":0.2364154659782713,"score_spread":0.2290881625287852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}