{"id":"W2419532052","doi":"10.1002/psc.2884","title":"Site‐specific conjugation of the quencher on peptide's N‐terminal for the synthesis of a targeted non‐spreading activatable optical probe","year":2016,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Victoria; University of Alberta; IONICS Mass Spectrometry (Canada); University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Carbodiimide; Conjugate; Chemistry; Peptide; Fluorescence; Combinatorial chemistry; Yield (engineering); Bioconjugation; Protecting group; Lysine; Amino acid; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865231,0.0003152866,0.0002665894,0.0001473031,0.0001227469,0.0001714183,0.0003280237,0.0004667511,0.0008537983],"category_scores_gemma":[0.0001762184,0.0001458265,0.0002788808,0.0001553976,0.0002240444,0.0002766038,0.0002118714,0.0006270348,0.0005010224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926319,"about_ca_system_score_gemma":0.0002145064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000230219,"about_ca_topic_score_gemma":0.0004441225,"domain_scores_codex":[0.9998819,0.00001324715,0.000009427259,0.00004279278,0.00002883259,0.00002382327],"domain_scores_gemma":[0.9998639,0.00003403951,0.00004105608,0.00002567629,0.00001899449,0.00001643788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008524825,0.000007035138,0.00001979385,0.00003409166,0.000001184558,0.00002483892,0.000007593424,0.00003813678,0.9989222,0.00008169129,0.000008417749,0.0008463573],"study_design_scores_gemma":[0.000002922838,0.00007573291,0.0003542754,0.000002214712,0.0000045259,0.0001416062,0.000003506017,0.0002995909,0.9977621,0.00002197766,0.001328404,0.000003177304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.920015,0.002476592,0.07417209,0.0001481422,0.0000897276,0.0002085549,0.0001692408,0.0001500275,0.002570526],"genre_scores_gemma":[0.9229143,0.002119298,0.06781396,0.0001697463,0.00003887932,0.0001529247,0.0003461705,0.00004821778,0.006396603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008537983,"threshold_uncertainty_score":0.002856255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966325089442017,"score_gpt":0.2690810884330642,"score_spread":0.249417837538644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}