{"id":"W2419535793","doi":"10.1021/acs.analchem.5b04524","title":"Trimethylation Enhancement Using <sup>13</sup>C-Diazomethane (<sup>13</sup>C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine, and Phosphatidylserine Lipids Derived from Complex Biological Samples","year":2016,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Carleton University","keywords":"Chemistry; Phosphatidylethanolamine; Phosphatidylcholine; Diazomethane; Phosphatidylserine; Detection limit; Phospholipid; Chromatography; Derivatization; Mass spectrometry; Sphingomyelin; Analytical Chemistry (journal); Biochemistry; Membrane; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004683282,0.0005978942,0.0008910987,0.00006188743,0.0001442657,0.00004481291,0.0001922431,0.0005563631,0.0003278302],"category_scores_gemma":[0.0007205823,0.0004605699,0.0002016163,0.0002817667,0.0006395871,0.00003855042,0.0003182892,0.0002327508,0.000002182142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000598435,"about_ca_system_score_gemma":0.0001344935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007642744,"about_ca_topic_score_gemma":0.00002987741,"domain_scores_codex":[0.996987,0.0002034149,0.0007087091,0.001140685,0.0003591673,0.0006010353],"domain_scores_gemma":[0.9980806,0.000411283,0.0003067123,0.0005799021,0.000236921,0.0003846242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005298097,0.0002130284,0.05215145,0.00009296468,0.0002275796,0.000008535606,0.00004582954,0.00003756729,0.9391652,0.000008259006,0.00003703165,0.007482779],"study_design_scores_gemma":[0.002723343,0.0002132865,0.05162145,0.00007348561,0.0002693673,0.00003131247,0.00006456581,0.003986112,0.9399669,0.00004323709,0.0004472694,0.000559734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948652,0.0005697975,0.003520733,0.0001116835,0.00003071746,0.0003029258,0.0004461851,0.00003714678,0.0001155793],"genre_scores_gemma":[0.9944655,0.0005967669,0.003471927,0.0001358507,0.0004696394,0.00001624765,0.0006930506,0.00004413649,0.000106889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006923045,"threshold_uncertainty_score":0.9997846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489654628620611,"score_gpt":0.2669778932964717,"score_spread":0.2420813470102656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}