{"id":"W2419535793","doi":"10.1021/acs.analchem.5b04524","title":"Trimethylation Enhancement Using <sup>13</sup>C-Diazomethane (<sup>13</sup>C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine, and Phosphatidylserine Lipids Derived from Complex Biological Samples","year":2016,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Carleton University","keywords":"Chemistry; Phosphatidylethanolamine; Phosphatidylcholine; Diazomethane; Phosphatidylserine; Detection limit; Phospholipid; Chromatography; Derivatization; Mass spectrometry; Sphingomyelin; Analytical Chemistry (journal); Biochemistry; Membrane; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004250207,0.0007752503,0.0002999779,0.0002689848,0.0001760278,0.0002823798,0.0004513085,0.0005513816,0.001352047],"category_scores_gemma":[0.0006246828,0.0003427743,0.0003515023,0.0002536072,0.0004329444,0.0004285501,0.0004397848,0.0009134292,0.0006926516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572457,"about_ca_system_score_gemma":0.0003563776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008750753,"about_ca_topic_score_gemma":0.001463496,"domain_scores_codex":[0.9997932,0.00003026235,0.00001132412,0.00006921283,0.00006493033,0.00003108776],"domain_scores_gemma":[0.9997309,0.00008350434,0.0000658041,0.00002188536,0.00007540392,0.00002250492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005629599,0.00000296712,0.00009538962,0.00003902545,0.000006297817,0.00004338525,0.00001539352,0.00003409042,0.9980812,0.00004490388,0.00004191481,0.00153915],"study_design_scores_gemma":[0.000003410074,0.00004603434,0.0005251734,0.000002977294,0.000009976999,0.0001336062,0.000008520256,0.0003091364,0.9980556,0.00002428744,0.000876338,0.000004914808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9202746,0.006037716,0.06515139,0.0006740931,0.0001759733,0.0001758329,0.001055462,0.0007717917,0.005683291],"genre_scores_gemma":[0.9292795,0.005662732,0.05730076,0.0008256067,0.00007645843,0.0002216802,0.001268663,0.0002149836,0.005149664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001352047,"threshold_uncertainty_score":0.004523039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489654628620611,"score_gpt":0.2669778932964717,"score_spread":0.2420813470102656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}