{"id":"W2419551149","doi":"10.1021/acs.molpharmaceut.5b00233","title":"Efficient Delivery of Structurally Diverse Protein Cargo into Mammalian Cells by a Bacterial Toxin","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Diphtheria toxin; Intracellular; Chimera (genetics); Toxin; Cell biology; Microbial toxins; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003149165,0.0002648197,0.0003084274,0.0001591975,0.0001546383,0.0005434355,0.0001599045,0.0004256066,0.0002735787],"category_scores_gemma":[0.0001753688,0.0001683586,0.000199676,0.0001790592,0.0003420558,0.0003712161,0.000416508,0.0004801205,0.0002419646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004641135,"about_ca_system_score_gemma":0.0002818029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003865641,"about_ca_topic_score_gemma":0.0004417925,"domain_scores_codex":[0.9998114,0.0000310001,0.00002109365,0.00004350997,0.00006014388,0.000032861],"domain_scores_gemma":[0.999928,0.00001706933,0.00002050069,0.00001431603,0.000007810573,0.00001221886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008175786,0.000003751693,0.00004488813,0.00001171878,0.000001328239,0.0000143238,0.000008895993,0.00004481622,0.9992688,0.0001459423,0.000006636898,0.0004406954],"study_design_scores_gemma":[0.000004646277,0.0001088333,0.0004365213,0.000002949345,0.000005697713,0.0001073562,0.0000108409,0.0004979131,0.9973347,0.00005078597,0.001437875,0.000001903881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675349,0.002066614,0.02851959,0.0001887643,0.00002603635,0.00007558551,0.0001800597,0.0001186607,0.001289832],"genre_scores_gemma":[0.9723421,0.002071555,0.02329062,0.0001124932,0.000007731612,0.00005502305,0.0003000645,0.00003923509,0.001781244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005434355,"threshold_uncertainty_score":0.003367364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609930032738509,"score_gpt":0.2542574379652057,"score_spread":0.2381581376378206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}