{"id":"W2419581276","doi":"10.1016/j.talanta.2016.05.074","title":"A nontargeted screening method for covalent DNA adducts and DNA modification selectivity using liquid chromatography-tandem mass spectrometry","year":2016,"lang":"en","type":"article","venue":"Talanta","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"Chemistry; Adduct; Thymine; DNA; Guanine; Covalent bond; Styrene oxide; Oligonucleotide; Selectivity; Glycidyl methacrylate; Tandem mass spectrometry; Chromatography; Mass spectrometry; Moiety; Chemical ionization; Styrene; Organic chemistry; Ion; Nucleotide; Biochemistry; Ionization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378426,0.00144593,0.0009366785,0.001542641,0.0008270245,0.0007381883,0.001893691,0.001754537,0.001066014],"category_scores_gemma":[0.001646079,0.0008824756,0.0005874106,0.0005999117,0.0005840565,0.0007642567,0.00106371,0.001302167,0.001344946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006084948,"about_ca_system_score_gemma":0.001312893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007958126,"about_ca_topic_score_gemma":0.002359774,"domain_scores_codex":[0.9967712,0.0004388319,0.0001194023,0.0007489755,0.001716321,0.0002052475],"domain_scores_gemma":[0.9987707,0.0003550181,0.0001696961,0.0001508229,0.0004440824,0.0001097393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005496952,0.00005040968,0.000334415,0.00004912492,0.00002958841,0.00005154599,0.00001678872,0.00005021564,0.9924729,0.0001157877,0.000207192,0.006567055],"study_design_scores_gemma":[0.000007881207,0.0001489162,0.0006769071,0.000003988756,0.00003402962,0.0003820803,0.000009953757,0.001998056,0.9954714,0.00007801451,0.001168433,0.0000204493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2822979,0.00539002,0.6976779,0.0007731947,0.0003642815,0.001047294,0.001274592,0.006084482,0.005090361],"genre_scores_gemma":[0.5882369,0.003077426,0.3904515,0.001938602,0.0001312274,0.001036137,0.001644318,0.0002612332,0.01322267],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001893691,"threshold_uncertainty_score":0.007289946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01880523012019983,"score_gpt":0.2798358745223464,"score_spread":0.2610306444021466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}