{"id":"W2419582720","doi":"10.1097/ppo.0000000000000134","title":"A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment","year":2015,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medicine; Chemotherapy; Metastasis; Breast cancer; Oncology; Melanoma; Cancer; Bevacizumab; Primary tumor; Metastatic breast cancer; Clinical trial; Tumor microenvironment; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01625955,0.001271689,0.001658378,0.001673826,0.0006553408,0.002309567,0.002077422,0.002329881,0.00272551],"category_scores_gemma":[0.004549483,0.0006045982,0.001150076,0.001202013,0.002888396,0.002762983,0.00189896,0.004985609,0.0009342115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001857011,"about_ca_system_score_gemma":0.002282629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405252,"about_ca_topic_score_gemma":0.001812752,"domain_scores_codex":[0.9967538,0.001593781,0.0002884612,0.0006321028,0.0005077551,0.0002241626],"domain_scores_gemma":[0.9873025,0.005032673,0.001359215,0.001944731,0.003043831,0.001316928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001480922,0.003524964,0.01245474,0.005692504,0.000383181,0.0006091837,0.001159387,0.00685238,0.634424,0.03560662,0.007564323,0.2902478],"study_design_scores_gemma":[0.0003783322,0.02031648,0.02133386,0.002753475,0.0007551614,0.008791057,0.001094293,0.007249477,0.5661144,0.0167695,0.354153,0.0002910022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.2522016,0.3214809,0.3782572,0.01587543,0.001324436,0.001367852,0.001512231,0.001225999,0.02675449],"genre_scores_gemma":[0.3717369,0.3172907,0.2837092,0.007534803,0.001090128,0.001615717,0.003836663,0.0004286708,0.01275717],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01625955,"threshold_uncertainty_score":0.08598977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0844223888402573,"score_gpt":0.4154907734175812,"score_spread":0.3310683845773239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}