{"id":"W2419582720","doi":"10.1097/ppo.0000000000000134","title":"A Decade of Experience in Developing Preclinical Models of Advanced- or Early-Stage Spontaneous Metastasis to Study Antiangiogenic Drugs, Metronomic Chemotherapy, and the Tumor Microenvironment","year":2015,"lang":"en","type":"review","venue":"The Cancer Journal","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medicine; Chemotherapy; Metastasis; Breast cancer; Oncology; Melanoma; Cancer; Bevacizumab; Primary tumor; Metastatic breast cancer; Clinical trial; Tumor microenvironment; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000961778,0.0002600221,0.0009452893,0.00008132459,0.00006331279,0.00002374011,0.0006244748,0.00005642312,0.00002402094],"category_scores_gemma":[0.00003880043,0.0001308534,0.0002474961,0.0001598191,0.0001945366,0.000007005196,0.0002899628,0.0002229627,5.673144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208874,"about_ca_system_score_gemma":0.0006896553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003346448,"about_ca_topic_score_gemma":0.0003508232,"domain_scores_codex":[0.9980168,0.0004235901,0.0006758348,0.0003346099,0.000262704,0.0002864607],"domain_scores_gemma":[0.9989002,0.00006930526,0.000452628,0.0004132266,0.00004722647,0.0001174241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004649315,0.0002827728,0.0002273356,0.000495659,0.002452943,0.0001060603,0.003800578,0.0004198964,0.0001630681,0.00000536896,0.00005334018,0.9873437],"study_design_scores_gemma":[0.03812905,0.007510799,0.001225431,0.009714249,0.004543859,0.003476233,0.0104306,0.00006502705,0.01331491,0.0002977511,0.9089363,0.002355821],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.359197,0.6396703,0.00006159265,0.00003950268,0.00003211852,0.0009323998,0.00006283663,6.928177e-7,0.00000354591],"genre_scores_gemma":[0.1063273,0.8928365,0.0004014979,0.00004303723,0.00006181833,0.0002457352,0.000003566091,0.00003027393,0.00005024041],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849879,"threshold_uncertainty_score":0.5336047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0844223888402573,"score_gpt":0.4154907734175812,"score_spread":0.3310683845773239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}