{"id":"W2419675532","doi":"10.1371/journal.pone.0156055","title":"Gene Expression Deconvolution for Uncovering Molecular Signatures in Response to Therapy in Juvenile Idiopathic Arthritis","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Saskatchewan; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of British Columbia; IWK Health Centre; University of Alberta; Arthritis Society; University of Ottawa; McGill University; McGill University Health Centre; Université de Sherbrooke; University of Toronto; Canadian Arthritis Network; BC Children's Hospital; University of Manitoba; Hospital for Sick Children; University of Saskatchewan","keywords":"Arthritis; Gene expression; In silico; Computational biology; Gene; Bonferroni correction; Biology; Gene expression profiling; Bioinformatics; Immunology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007777785,0.0001042667,0.0003295389,0.0002881106,0.00003147688,0.00000849042,0.00008434219,0.0001167256,0.00007039289],"category_scores_gemma":[0.0007861065,0.00008134688,0.0000468319,0.0001848579,0.00002116905,0.0001044295,0.00003888791,0.0001357942,0.00002272164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655236,"about_ca_system_score_gemma":0.0001649424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002051723,"about_ca_topic_score_gemma":0.00002613698,"domain_scores_codex":[0.9987256,0.0001271702,0.0003215058,0.0002429369,0.0002851488,0.0002976653],"domain_scores_gemma":[0.9994591,0.00009885398,0.00004229994,0.0002521943,0.000075235,0.00007228721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004862864,0.0004565273,0.004033288,0.00005070536,0.00001517551,0.00005445519,0.0002438906,0.00002613123,0.9768434,0.000007151308,0.00005335419,0.01335308],"study_design_scores_gemma":[0.005191623,0.000868934,0.02074941,0.002382235,0.000003383158,0.000001092261,0.00004501861,0.00008655011,0.9698949,0.0002482378,0.0004066988,0.0001218835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910266,0.005677711,0.0006519156,0.001560265,0.00001516543,0.0009845227,0.000005843135,0.00002908472,0.0000489343],"genre_scores_gemma":[0.9971356,0.0008608475,0.001050933,0.0002341588,0.00002804311,0.0003564154,0.000003190265,0.00002702401,0.0003038163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01671612,"threshold_uncertainty_score":0.3317229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02846182144303458,"score_gpt":0.2738763466218178,"score_spread":0.2454145251787832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}