{"id":"W2420643599","doi":"","title":"Dynamic regulation of cAMP signaling by cGMP in the cardiovascular system: roles of phosphodiesterase 2 and phosphodiesterase 3 enzymes.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Phosphodiesterase; PDE10A; Phosphodiesterase 3; cGMP-specific phosphodiesterase type 5; Enzyme; Signal transduction; Chemistry; Cell biology; Pharmacology; Internal medicine; Biology; Biochemistry; Medicine; Sildenafil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009768341,0.0001559234,0.0002813581,0.00007962365,0.00003710831,0.00001392094,0.00009710569,0.0001246445,0.000002173603],"category_scores_gemma":[0.00009129073,0.0001251942,0.0001131833,0.0001824075,0.00009859112,0.00001257412,0.00002487053,0.00007078984,2.364512e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003565026,"about_ca_system_score_gemma":0.00002361166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007038937,"about_ca_topic_score_gemma":0.00008503265,"domain_scores_codex":[0.9986251,0.0002488056,0.0004192196,0.0002854882,0.0002022719,0.0002191198],"domain_scores_gemma":[0.9993622,0.00003784139,0.0001547179,0.000344086,0.0000603953,0.00004081508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002269691,0.001541033,0.2624744,0.003515685,0.001523604,0.00006579509,0.007300137,0.02929998,0.5738209,0.004017706,0.001412926,0.1127581],"study_design_scores_gemma":[0.00350028,0.0001039099,0.2062205,0.0001344349,0.0001236124,0.00007748434,0.002281327,0.0006651762,0.7806364,0.00009385063,0.005726663,0.000436354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822606,0.01604672,0.000592512,0.00002956086,0.0001138987,0.0006149335,0.00001830075,0.000005795499,0.0003176912],"genre_scores_gemma":[0.999254,0.0002217181,0.00008036644,0.00003874243,0.000009681052,0.0002460409,0.00005819806,0.00001408403,0.00007710159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2068155,"threshold_uncertainty_score":0.5105271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005908878386823313,"score_gpt":0.1829537817163446,"score_spread":0.1770449033295213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}