{"id":"W2420922808","doi":"10.1093/bioinformatics/btw280","title":"DFLpred: High-throughput prediction of disordered flexible linker regions in protein sequences","year":2016,"lang":"en","type":"article","venue":"Bioinformatics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Proteome; Linker; Computer science; Human proteome project; Sequence (biology); Intrinsically disordered proteins; Throughput; Domain (mathematical analysis); Computational biology; Protein domain; Biological system; Chemistry; Biology; Bioinformatics; Proteomics; Mathematics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141032,0.0001263301,0.0001430775,0.00006286555,0.00003487147,0.000009973288,0.0001696879,0.0001958081,0.000009953663],"category_scores_gemma":[0.00008793424,0.0000867007,0.00005224811,0.0001215236,0.0001225085,0.00002204553,0.0000832525,0.00005476067,0.000006791903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001979234,"about_ca_system_score_gemma":0.00009678954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003810576,"about_ca_topic_score_gemma":0.00003920468,"domain_scores_codex":[0.9991229,0.00002055812,0.0003981413,0.0001307927,0.0001339472,0.0001936629],"domain_scores_gemma":[0.9993778,0.000007944979,0.0001675886,0.000341218,0.00006326034,0.000042139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002810614,0.0001583126,0.009043518,0.000414113,0.0001218301,0.00000246582,0.0007070508,0.000253554,0.916633,0.01502144,0.002393759,0.05496991],"study_design_scores_gemma":[0.004213653,0.001538562,0.01216959,0.0006261717,0.00004525138,0.00003469076,0.0005865584,0.00342706,0.9176103,0.0237678,0.03519609,0.0007842189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8365309,0.0002661734,0.1588262,0.0005128076,0.0002056392,0.0008010195,0.0003187649,0.00005292388,0.00248553],"genre_scores_gemma":[0.9786438,0.0002127007,0.02010832,0.00005646039,0.00007698707,0.00004095246,0.0001124611,0.00001180218,0.0007365562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1421128,"threshold_uncertainty_score":0.3535552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032184592350963,"score_gpt":0.2276456780206788,"score_spread":0.2173238320971691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}