{"id":"W2421289519","doi":"10.4238/gmr.15028579","title":"Altered expression of CG5961, a putative Drosophila melanogaster homologue of FBXO9, provides a new model of Parkinson disease","year":2016,"lang":"en","type":"article","venue":"Genetics and Molecular Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Drosophila melanogaster; Biology; Gene; Genetics; Melanogaster; RNA interference; Neurodegeneration; Gene expression; Dopaminergic; Cell biology; Neuroscience; Disease; RNA; Dopamine; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003415813,0.0001380894,0.0002106341,0.00008296894,0.00005125883,0.00001157471,0.0002850152,0.000119834,0.000007624923],"category_scores_gemma":[0.000200674,0.00010291,0.00008542094,0.00006187915,0.0004255187,0.000004445681,0.0004448242,0.00007455404,5.924078e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005873494,"about_ca_system_score_gemma":0.0002205975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002592487,"about_ca_topic_score_gemma":0.000002991063,"domain_scores_codex":[0.9985622,0.0001858477,0.0002879678,0.0003658815,0.0003210218,0.0002770381],"domain_scores_gemma":[0.9988223,0.00002907175,0.0001544398,0.0005081584,0.0002724502,0.0002136126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004172593,0.00008817055,0.001159529,0.0001303415,0.00003093422,0.000002633684,0.000106496,0.00003834215,0.9932048,0.0001639302,0.000367619,0.004289909],"study_design_scores_gemma":[0.0008705995,0.0006478371,0.0004982378,0.0001221221,0.00001381196,0.000001263735,0.0000256341,0.0002658204,0.9930889,0.003563105,0.0007901334,0.0001125376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844412,0.003326417,0.01105847,0.000256751,0.00001386798,0.0004384824,0.0002905207,0.00000215896,0.0001721365],"genre_scores_gemma":[0.9959077,0.001098303,0.002616321,0.00002342478,0.00003038768,0.00003430888,0.00002820923,0.00002495085,0.000236344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01146655,"threshold_uncertainty_score":0.4196548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05609687336722361,"score_gpt":0.3245394797299355,"score_spread":0.2684426063627118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}