{"id":"W2421324379","doi":"10.1021/acs.est.6b02211","title":"Equol Induces Gonadal Intersex in Japanese Medaka (<i>Oryzias latipes</i>) at Environmentally Relevant Concentrations: Comparison with 17β-Estradiol","year":2016,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"State Administration of Foreign Experts Affairs; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China; Canada Research Chairs","keywords":"Oryzias; Equol; Methyltestosterone; Internal medicine; Endocrinology; Estrogen; Biology; Endocrine disruptor; Estrogen receptor; EC50; Chemistry; Fish <Actinopterygii>; Hormone; Medicine; In vitro; Endocrine system; Biochemistry; Daidzein; Fishery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000091825,0.0003816923,0.000210455,0.0002824894,0.0001737317,0.0002389945,0.0001417256,0.0002403652,0.001345405],"category_scores_gemma":[0.0001294225,0.0001901335,0.0003284252,0.00009918035,0.000276503,0.0001846322,0.0003092115,0.0004364361,0.0001585485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003578241,"about_ca_system_score_gemma":0.0002448936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00298035,"about_ca_topic_score_gemma":0.00731898,"domain_scores_codex":[0.9998699,0.0000161988,0.00001295243,0.00003873178,0.0000315808,0.00003055037],"domain_scores_gemma":[0.9998567,0.00001962127,0.00005902299,0.0000112862,0.00002119365,0.00003218507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001677231,0.00003421448,0.001160841,0.00004180285,0.0000123021,0.00005559006,0.00003894024,0.00005257101,0.9974486,0.00002513445,0.0000189121,0.0009433305],"study_design_scores_gemma":[0.00002085472,0.002410729,0.03816852,0.0000105414,0.000066037,0.0001681977,0.0002299078,0.0002948409,0.9569099,0.00003139183,0.001676746,0.00001235402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998696,0.0002261968,0.0002640239,0.00003532392,0.00000940601,0.00001606288,0.0001279536,0.00001845282,0.0006066297],"genre_scores_gemma":[0.9952638,0.0004436186,0.000441327,0.00009497152,0.00000609885,0.00003455313,0.0002940508,0.00001366366,0.003408004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00298035,"threshold_uncertainty_score":0.005926013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008449442972336801,"score_gpt":0.2294340600010141,"score_spread":0.2209846170286773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}