{"id":"W2422274351","doi":"10.1093/neuonc/now076.20","title":"MB-22ACTIVATED Wnt SIGNALING FOR THE THERAPEUTIC TARGETING OF TREATMENT-REFRACTORY MEDULLOBLASTOMA STEM CELLS","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medulloblastoma; Wnt signaling pathway; Refractory (planetary science); Stem cell; Cancer research; Medicine; Biology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009258962,0.000216161,0.0002110293,0.0002473661,0.0001071489,0.0002414208,0.0001396114,0.0001479681,0.0009421033],"category_scores_gemma":[0.00005121973,0.00009024003,0.0001830446,0.0001525007,0.0001230558,0.0001169682,0.0001319268,0.0003911624,0.0001981264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599085,"about_ca_system_score_gemma":0.0002795359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008955456,"about_ca_topic_score_gemma":0.002639133,"domain_scores_codex":[0.9999471,0.000008425638,0.000004096975,0.000008110022,0.00002018461,0.00001219836],"domain_scores_gemma":[0.9999819,0.000002282184,0.000005970169,0.000001913515,0.000001733625,0.000006192862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002198526,0.0001289223,0.0002566776,0.0001040318,0.00001587456,0.0001203735,0.00004107534,0.0004424727,0.9836864,0.000401123,0.0002721715,0.01431104],"study_design_scores_gemma":[0.0001453409,0.001693636,0.003799367,0.00001820681,0.00007700478,0.0006548284,0.00003392337,0.002622783,0.974803,0.00008505576,0.01605618,0.00001050871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842382,0.006541746,0.004228271,0.0002262035,0.00006534671,0.0001676997,0.0004756213,0.0001712302,0.003885653],"genre_scores_gemma":[0.9925433,0.003073429,0.002221763,0.00004549111,0.00001020806,0.00008007806,0.0003917286,0.0000143514,0.001619716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009421033,"threshold_uncertainty_score":0.003151655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415089303889892,"score_gpt":0.2769191817095702,"score_spread":0.2527682886706712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}