{"id":"W2422906106","doi":"10.1021/pr200840b","title":"Environmental Contaminant Mixtures at Ambient Concentrations Invoke a Metabolic Stress Response in Goldfish Not Predicted from Exposure to Individual Compounds Alone","year":2011,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Toxicant; Metabolomics; Environmental chemistry; Phthalate; Nonylphenol; Pollutant; Contamination; Adverse Outcome Pathway; Metabolite; Ecotoxicology; Environmental toxicology; Chemistry; Biology; Toxicity; Ecology; Bioinformatics; Biochemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002493466,0.0002004089,0.0004063003,0.0002381988,0.0001960933,0.00006758573,0.0007144649,0.0001092689,0.000974999],"category_scores_gemma":[0.0005909616,0.0001534633,0.0001113487,0.0003650069,0.0003987221,0.0002702057,0.0006659775,0.0007826599,0.00007658045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004408179,"about_ca_system_score_gemma":0.00005789391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001138569,"about_ca_topic_score_gemma":0.0002858329,"domain_scores_codex":[0.9957604,0.0009395084,0.0006922185,0.0003577615,0.001594739,0.0006554007],"domain_scores_gemma":[0.9984549,0.0004976294,0.0002356717,0.0003222507,0.00003837697,0.0004512322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002433398,0.0006002969,0.2268954,0.000006669504,0.0000494306,0.0002716566,0.003457944,0.00004915012,0.764859,0.000002736509,0.0010965,0.0002777639],"study_design_scores_gemma":[0.001209159,0.0009057953,0.6092523,0.00008399208,0.00001615353,0.00002905505,0.0003985676,0.000021215,0.387062,0.00003735064,0.0008621228,0.0001222589],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979686,0.0002384281,0.00001205671,0.000458674,0.00008304959,0.0008333104,0.0002843547,0.000008832828,0.0001127456],"genre_scores_gemma":[0.9977304,0.0001017188,0.001709975,0.00008483865,0.00009725501,0.00006726186,0.00001802897,0.00002280091,0.000167679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3823569,"threshold_uncertainty_score":0.9999382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04507279455587371,"score_gpt":0.3486002443772643,"score_spread":0.3035274498213906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}