{"id":"W2422917950","doi":"10.1158/1078-0432.ccr-15-1314","title":"Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Biology; DNA damage; Kinase; Phosphorylation; Cancer research; Cancer cell; DNA repair; Protein kinase A; Cancer; Caspase; Cell biology; Apoptosis; Programmed cell death; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236202,0.0005337903,0.0002375148,0.0003042902,0.0002186726,0.0006847751,0.0002401817,0.0003982653,0.001550746],"category_scores_gemma":[0.0001034634,0.0001352719,0.0002725872,0.0002827761,0.0002463491,0.0006580728,0.0003012467,0.0008778283,0.0004406808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007607862,"about_ca_system_score_gemma":0.0004287613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003345053,"about_ca_topic_score_gemma":0.000639529,"domain_scores_codex":[0.9998804,0.0000185492,0.00000757619,0.00002482673,0.00004171401,0.00002683243],"domain_scores_gemma":[0.9999444,0.000003671578,0.00001410121,0.000004797522,0.00001723896,0.0000157699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006970599,0.0001829193,0.0007939817,0.0007172855,0.00004784832,0.0002199705,0.00004394546,0.0004966419,0.9595551,0.005095747,0.001836534,0.030313],"study_design_scores_gemma":[0.0001927346,0.0009856408,0.006042396,0.00006941032,0.00008528777,0.001503855,0.00006445968,0.002196788,0.9049897,0.001814472,0.08203471,0.00002051164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6660177,0.2448037,0.03899925,0.008187125,0.001441263,0.0005306661,0.0016475,0.0006378466,0.0377351],"genre_scores_gemma":[0.9093695,0.06109106,0.008964759,0.001218072,0.0002943245,0.0002600837,0.0009089684,0.00003361597,0.01785951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550746,"threshold_uncertainty_score":0.005519867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07282055038973116,"score_gpt":0.4010784169604375,"score_spread":0.3282578665707063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}