{"id":"W2423433037","doi":"10.18632/oncotarget.12015","title":"SIRT2 deletion enhances KRAS-induced tumorigenesis <i>in vivo</i> by regulating K147 acetylation status","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; York University; Vanderbilt University","keywords":"KRAS; SIRT2; Cancer research; Carcinogenesis; Cancer; Acetylation; Medicine; Internal medicine; Biology; Oncology; Sirtuin; Colorectal cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623997,0.0003765269,0.0002587178,0.0003041983,0.0001844237,0.0004761867,0.0002566046,0.0004047648,0.004444247],"category_scores_gemma":[0.0001105071,0.0002462523,0.0004633746,0.000181763,0.0003843493,0.0002430981,0.0002582828,0.0009137295,0.001405689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003595123,"about_ca_system_score_gemma":0.0002970423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006035005,"about_ca_topic_score_gemma":0.001117059,"domain_scores_codex":[0.9997762,0.00002961226,0.00002833077,0.00004604321,0.0000526851,0.0000671716],"domain_scores_gemma":[0.9998314,0.00001579626,0.00005469216,0.00002362897,0.00001248565,0.00006190511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004214319,0.00007896172,0.0004410614,0.00003633318,0.000009074515,0.00004511094,0.00001290363,0.00005394786,0.9972051,0.000119831,0.0002193314,0.001356928],"study_design_scores_gemma":[0.00003405391,0.0004326466,0.004659883,0.000006708157,0.00001595304,0.0001590403,0.00004515189,0.0009594817,0.991648,0.00005522995,0.001977695,0.000006133249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885494,0.001204335,0.003278193,0.0004631439,0.000177453,0.00003989547,0.0009735746,0.0006232458,0.00469064],"genre_scores_gemma":[0.9924366,0.0005102862,0.001224773,0.00012665,0.00001574449,0.00002956921,0.0007377816,0.00008458486,0.004833915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004444247,"threshold_uncertainty_score":0.01486748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099586020597357,"score_gpt":0.2709848012519918,"score_spread":0.2599889410460182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}