{"id":"W2423433037","doi":"10.18632/oncotarget.12015","title":"SIRT2 deletion enhances KRAS-induced tumorigenesis <i>in vivo</i> by regulating K147 acetylation status","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; York University; Vanderbilt University","keywords":"KRAS; SIRT2; Cancer research; Carcinogenesis; Cancer; Acetylation; Medicine; Internal medicine; Biology; Oncology; Sirtuin; Colorectal cancer; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004117889,0.000212131,0.0003980258,0.0001360743,0.00008720009,0.00001312303,0.00007388034,0.0001504909,0.0006182988],"category_scores_gemma":[0.0002426413,0.0001337349,0.00008041658,0.0002880958,0.00005794605,0.0001619013,0.00002419732,0.0001457381,0.0000490808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544849,"about_ca_system_score_gemma":0.0001155571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001938165,"about_ca_topic_score_gemma":0.00005528548,"domain_scores_codex":[0.9981133,0.00007915725,0.0004574583,0.0003940981,0.0004677352,0.0004882202],"domain_scores_gemma":[0.9990855,0.0001459635,0.0001591934,0.0002998865,0.0001047921,0.0002046842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001904935,0.0001012087,0.06111376,0.00003291438,0.00002277634,0.00001685283,0.0001724765,0.000003834456,0.921062,0.00004169153,0.009667305,0.00757468],"study_design_scores_gemma":[0.007051052,0.001061411,0.08235546,0.0008888112,0.00009748604,0.00003339404,0.0004023122,0.0005612764,0.8270568,0.0002134278,0.07982308,0.0004554613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914811,0.0007729229,0.0007671138,0.002985067,0.0004860087,0.0003420516,0.0000157893,0.00008621695,0.003063745],"genre_scores_gemma":[0.9936315,0.0005482202,0.001036662,0.000501988,0.0006415202,0.0000322216,0.00003614512,0.00003731945,0.003534436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09400519,"threshold_uncertainty_score":0.6769938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099586020597357,"score_gpt":0.2709848012519918,"score_spread":0.2599889410460182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}