{"id":"W2424565233","doi":"10.1097/mib.0000000000000808","title":"The Next Wave of Biological Agents for the Treatment of IBD","year":2016,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"ActoGeniX","keywords":"Vedolizumab; Ustekinumab; Medicine; Ulcerative colitis; Inflammatory bowel disease; Crohn's disease; Immunogenicity; Disease; Monoclonal antibody; MEDLINE; Immunology; Intensive care medicine; Bioinformatics; Internal medicine; Infliximab; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001819673,0.0006382671,0.001566637,0.002013043,0.0002612942,0.001304199,0.0006791445,0.001412288,0.007953225],"category_scores_gemma":[0.001903497,0.0002313932,0.001491813,0.001608124,0.000486614,0.002490882,0.0009359362,0.002989365,0.002248626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008068494,"about_ca_system_score_gemma":0.001691613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001474149,"about_ca_topic_score_gemma":0.003554983,"domain_scores_codex":[0.9992963,0.0002404436,0.0001036182,0.00005575165,0.0002482027,0.00005554054],"domain_scores_gemma":[0.9991577,0.0004627578,0.0001406444,0.00003014291,0.0001540415,0.00005480824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002223306,0.00006072561,0.0001609066,0.05764254,0.000348711,0.0001425606,0.0001123764,0.0001107268,0.001862456,0.005555733,0.03846533,0.8953156],"study_design_scores_gemma":[0.00009255743,0.000172504,0.0008639409,0.02327889,0.0003838847,0.0006579239,0.000119965,0.00003417767,0.0002811522,0.003004642,0.9710943,0.00001613475],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006792053,0.998415,0.00004665012,0.0006973094,0.0002225727,0.000005205376,0.000009375211,0.000003613759,0.0005323416],"genre_scores_gemma":[0.0007141117,0.9969851,0.0002340968,0.001206779,0.000252669,0.000008881497,0.00002146714,0.000001685673,0.0005751562],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007953225,"threshold_uncertainty_score":0.0266062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05742239017681937,"score_gpt":0.3135884372445772,"score_spread":0.2561660470677579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}