{"id":"W2424835261","doi":"10.3109/14756366.2016.1144595","title":"Niacin esters of chalcones with tumor-selective properties","year":2016,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Niacin; Chemistry; Cytotoxic T cell; Toxicity; Cytotoxicity; Pharmacology; Biochemistry; Stereochemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009334662,0.0005111495,0.0003624396,0.0003731631,0.0001229943,0.0002300309,0.0003129295,0.0002134082,0.003193207],"category_scores_gemma":[0.0001242302,0.00009820011,0.0001743176,0.0003555667,0.0001873942,0.0002632152,0.0002246065,0.0003470537,0.0007151762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303029,"about_ca_system_score_gemma":0.0002252402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003579033,"about_ca_topic_score_gemma":0.0009766732,"domain_scores_codex":[0.9999398,0.00001452783,0.000006856723,0.00001060336,0.00001437984,0.00001372294],"domain_scores_gemma":[0.9999332,0.000006431285,0.00001750113,0.000006379289,0.00001713026,0.00001927237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009842251,0.000194922,0.0004036745,0.0004874963,0.00002801557,0.0003613418,0.00004621996,0.001430755,0.9642875,0.000727839,0.000396403,0.03065156],"study_design_scores_gemma":[0.0001332456,0.003173654,0.002004363,0.00002873007,0.00003876993,0.0005355064,0.00003764963,0.0009375334,0.9764093,0.0001453863,0.01653412,0.0000215999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673049,0.008496126,0.008161125,0.000232895,0.0001154302,0.0002792531,0.0009800468,0.0002400545,0.01419008],"genre_scores_gemma":[0.9734266,0.005730873,0.006387321,0.0001912622,0.00003692054,0.0001334125,0.001293151,0.00003532035,0.01276511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003193207,"threshold_uncertainty_score":0.01068234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609851186731709,"score_gpt":0.2058752899905688,"score_spread":0.1897767781232517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}