{"id":"W2426482612","doi":"10.1039/c6md00228e","title":"Design, synthesis, biological evaluation and docking studies of sulfonyl isatin derivatives as monoamine oxidase and caspase-3 inhibitors","year":2016,"lang":"en","type":"article","venue":"MedChemComm","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"National Research Foundation","keywords":"Isatin; Monoamine oxidase; Sulfonyl; Chemistry; Docking (animal); Combinatorial chemistry; Monoamine neurotransmitter; Pharmacology; Stereochemistry; Biochemistry; Enzyme; Organic chemistry; Biology; Medicine; Serotonin; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002423111,0.0003779031,0.0003043857,0.0002047838,0.0001426586,0.0002016405,0.0003807407,0.0002354865,0.0009975234],"category_scores_gemma":[0.0001385996,0.0001368884,0.0002404051,0.0002606806,0.0001397975,0.0002294205,0.0001414499,0.0004199815,0.0002438835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266238,"about_ca_system_score_gemma":0.0002351791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007377547,"about_ca_topic_score_gemma":0.001886249,"domain_scores_codex":[0.9999304,0.00001465734,0.000005858879,0.000009565576,0.00002011089,0.00001936459],"domain_scores_gemma":[0.9999473,0.000004816528,0.00001757212,0.000004729309,0.0000132127,0.00001236148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009089109,0.0004297225,0.0003550242,0.0002634062,0.00005010013,0.0003294371,0.00008385866,0.007372975,0.9705945,0.0009991886,0.0004891806,0.01812387],"study_design_scores_gemma":[0.0004316302,0.006391315,0.001751401,0.00003300587,0.0001181487,0.000488388,0.00006329153,0.007483536,0.9708242,0.0002233235,0.01215658,0.00003506805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826822,0.006355422,0.006204614,0.0002291761,0.00005357577,0.0002142632,0.0004500471,0.00006810956,0.003742686],"genre_scores_gemma":[0.9841316,0.005769264,0.006901219,0.00006131298,0.00001021918,0.00006589338,0.000636322,0.00001251846,0.002411647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009975234,"threshold_uncertainty_score":0.003337026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138705424874091,"score_gpt":0.3535852096845828,"score_spread":0.2397146671971737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}