{"id":"W2426964365","doi":"10.1038/srep12704","title":"Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University","keywords":"ISG15; Ubiquitin; Ubiquitin-conjugating enzyme; Cell biology; Ubiquitins; Fusion protein; Proteasome; Crosstalk; Chemistry; Protein degradation; Ubiquitin ligase; Deubiquitinating enzyme; Protein turnover; Ubiquitin-Protein Ligases; Biology; Biochemistry; Protein biosynthesis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001598474,0.00009741377,0.0001262367,0.0001133962,0.00006559582,0.00007809507,0.00005253705,0.00008888472,0.000002551868],"category_scores_gemma":[0.0002880782,0.000100021,0.00001994765,0.000202548,0.00009016327,0.00001837347,0.00009990953,0.00004296952,5.567306e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000100108,"about_ca_system_score_gemma":0.00008087836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009991164,"about_ca_topic_score_gemma":0.00001944104,"domain_scores_codex":[0.9987198,0.00005381836,0.0004010539,0.0004818867,0.0001896321,0.0001538096],"domain_scores_gemma":[0.9991287,0.000003258234,0.0003284151,0.0002825982,0.0001733578,0.00008364216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001734643,0.00004250975,0.001395921,0.0000447866,0.000003993442,0.000002941116,0.0003646772,0.000003402863,0.9949026,0.00006734768,0.00001519641,0.003139338],"study_design_scores_gemma":[0.0002613208,0.00004582631,0.004518422,0.00005601788,0.000004221788,0.00005084641,0.0001674031,0.0007324871,0.9926656,0.0003302308,0.001056134,0.0001114154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984112,0.0003933286,0.0002590861,0.00006627115,0.0002605907,0.0004898877,0.00001318541,0.00000861129,0.00009779943],"genre_scores_gemma":[0.998747,0.000007059828,0.0002650097,0.000006985948,0.00003939268,0.00004963774,0.0001938629,0.00001130723,0.000679729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003122501,"threshold_uncertainty_score":0.407874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023217283267797,"score_gpt":0.2438158392645636,"score_spread":0.2235836664318856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}