{"id":"W2426964365","doi":"10.1038/srep12704","title":"Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University","keywords":"ISG15; Ubiquitin; Ubiquitin-conjugating enzyme; Cell biology; Ubiquitins; Fusion protein; Proteasome; Crosstalk; Chemistry; Protein degradation; Ubiquitin ligase; Deubiquitinating enzyme; Protein turnover; Ubiquitin-Protein Ligases; Biology; Biochemistry; Protein biosynthesis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871421,0.0003561725,0.000205946,0.0003699614,0.0001668783,0.000332999,0.0002896509,0.0003760078,0.0006635724],"category_scores_gemma":[0.0001697197,0.0001053172,0.0003641605,0.0002938949,0.0002228407,0.0002727841,0.0002144788,0.0003222749,0.0003915889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061762,"about_ca_system_score_gemma":0.0002046725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004178006,"about_ca_topic_score_gemma":0.0005164219,"domain_scores_codex":[0.9999253,0.000009891538,0.000009431607,0.00001868982,0.00002041866,0.00001641443],"domain_scores_gemma":[0.9998285,0.0000136655,0.00003510875,0.00002382536,0.00002655251,0.00007224619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007214958,0.00002065587,0.001039576,0.00002293557,0.00001327769,0.0001677574,0.00001202156,0.00007545292,0.996969,0.0002093607,0.00002207559,0.001375751],"study_design_scores_gemma":[0.00001549015,0.0004597789,0.025398,0.00001568758,0.00006949684,0.001614449,0.00006365807,0.0020929,0.9623751,0.0002284312,0.007655773,0.00001124652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913019,0.002341839,0.005140239,0.00007054283,0.0000250845,0.00004184825,0.0003011991,0.00001553753,0.0007617561],"genre_scores_gemma":[0.9874052,0.0009967256,0.007831369,0.00007914351,0.00001217667,0.00002036254,0.001799668,0.0000122572,0.001843113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006635724,"threshold_uncertainty_score":0.002221465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023217283267797,"score_gpt":0.2438158392645636,"score_spread":0.2235836664318856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}