{"id":"W2427406702","doi":"10.1177/1744806916653969","title":"Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development","year":2016,"lang":"en","type":"article","venue":"Molecular Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"CCR2; Dicer; Small interfering RNA; Cell biology; Gene silencing; Receptor; RNA interference; Gene knockdown; Chemokine; Pharmacology; Chemistry; Chemokine receptor; Biology; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001394965,0.0001820247,0.0002287516,0.00006943404,0.00004620407,0.000005390192,0.00004267498,0.0001059762,0.0006123976],"category_scores_gemma":[0.0002098062,0.0001300729,0.00009186391,0.0001216187,0.00003411028,0.00004309594,0.00002439414,0.00006274282,0.00006754546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001559441,"about_ca_system_score_gemma":0.00009982692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009490822,"about_ca_topic_score_gemma":0.000001646676,"domain_scores_codex":[0.9984724,0.0002751595,0.0003178591,0.0002871375,0.0004082145,0.0002392541],"domain_scores_gemma":[0.9993874,0.00007563319,0.0001203246,0.0002041502,0.00007355383,0.0001388661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011092,0.000494568,0.002261159,0.00006080301,0.0001681783,0.00003627429,0.00003512274,5.183715e-7,0.9252831,0.0001025937,0.005177141,0.06626966],"study_design_scores_gemma":[0.002992787,0.0003629611,0.003214446,0.0004050247,0.00004280032,0.000004843589,0.00002137882,0.00002268603,0.9838068,0.0003916509,0.008572184,0.0001624575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7773129,0.0002145775,0.2207842,0.0007845438,0.00006397377,0.0003975709,0.00002159357,0.00004776241,0.0003728702],"genre_scores_gemma":[0.9915476,0.00001793999,0.005415187,0.000678446,0.0000332472,0.00008249845,0.0002954964,0.00003069571,0.001898849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.215369,"threshold_uncertainty_score":0.6705325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013199066782111,"score_gpt":0.2161393621435861,"score_spread":0.206007371475765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}