{"id":"W2427933846","doi":"10.1016/j.bpj.2015.11.1357","title":"A Computational and Experimental Study of Cationic-Anionic Lipid Interactions: XTC2-DSPS as a Case Study","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; University of Calgary","funders":"","keywords":"Endosome; Cationic polymerization; Rational design; Chemistry; Lipid bilayer; Drug delivery; Membrane; Biophysics; Molecular dynamics; Biochemistry; Nanotechnology; Cell; Materials science; Computational chemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004815829,0.0005363076,0.0007579683,0.0005942182,0.0009480462,0.0010514,0.001559535,0.001903952,0.008908832],"category_scores_gemma":[0.001624883,0.0004310123,0.0004896338,0.0007413702,0.0008622499,0.0008056401,0.0006305384,0.00091911,0.0003661905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009789859,"about_ca_system_score_gemma":0.001421535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01813563,"about_ca_topic_score_gemma":0.01170764,"domain_scores_codex":[0.999844,0.00003408545,0.000005552825,0.00002448732,0.00003780411,0.00005407623],"domain_scores_gemma":[0.9984415,0.001164868,0.00007123938,0.00006821348,0.0001725205,0.00008159694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278443,0.000269998,0.002060414,0.0001698614,0.00003078715,0.0003807473,0.00005525079,0.9859746,0.001937803,0.00595163,0.0007987349,0.002242226],"study_design_scores_gemma":[0.00006116578,0.00007901269,0.0005088729,0.00000734552,0.00001282219,0.00004378836,0.00007481192,0.9967256,0.001087188,0.0009700822,0.0004204462,0.000008811228],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703311,0.0003209107,0.006109354,0.0006375309,0.00003408924,0.00004835448,0.0007737846,0.0001541763,0.02159076],"genre_scores_gemma":[0.9928821,0.0001681182,0.00425231,0.00008173668,0.00001376413,0.00005352101,0.0003256162,0.00003702374,0.002185797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01813563,"threshold_uncertainty_score":0.03606015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792145123790752,"score_gpt":0.3163079916983646,"score_spread":0.2983865404604571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}