{"id":"W2428071229","doi":"10.1038/srep20127","title":"Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lee Kong Chian School of Medicine, Nanyang Technological University; Conseil Régional Midi-Pyrénées; Université de Lausanne; Karolinska Institutet; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Nanyang Technological University; Medical Research Council; Canadian Institute for Advanced Research; Agence Nationale de la Recherche; National Science Foundation","keywords":"Biology; Nuclear receptor; Microbiome; Metabolome; Circadian clock; Gene expression; Circadian rhythm; Liver X receptor; Regulation of gene expression; Cell biology; Effector; Crosstalk; Pregnane X receptor; Lipid metabolism; Transcriptome; Endocrinology; Transcription factor; Gene; Biochemistry; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008802297,0.0002548383,0.0002844826,0.000368103,0.0005613567,0.0004132298,0.0001921529,0.0001244988,0.0006763922],"category_scores_gemma":[0.0007661398,0.0001801667,0.0001177555,0.0007189197,0.00103738,0.0003961042,0.0001212003,0.0001255216,0.0004918647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009211,"about_ca_system_score_gemma":0.0001442341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651979,"about_ca_topic_score_gemma":0.00001044548,"domain_scores_codex":[0.996885,0.0001336726,0.000560926,0.001399121,0.0003993197,0.0006219646],"domain_scores_gemma":[0.9981864,0.000131058,0.0003168064,0.000838085,0.00007745974,0.0004501681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005596644,0.00002394181,0.002873134,0.00001171989,0.000004099747,0.000275286,0.0006590189,4.61707e-7,0.9847552,0.0007924566,0.005146233,0.005452875],"study_design_scores_gemma":[0.0001760367,0.00003334526,0.000982787,0.0001073908,0.00001032628,0.0007800666,0.00007497847,0.00001168355,0.7537451,0.001623434,0.2421539,0.0003009502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887729,0.0001674711,0.00003378265,0.0005192418,0.008206703,0.0003552493,0.000008684749,0.0001787305,0.001757218],"genre_scores_gemma":[0.9921823,0.00005058352,0.00008968551,0.0001965833,0.00007745197,0.00001013103,0.000002221356,0.00004427681,0.007346749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2370077,"threshold_uncertainty_score":0.7406021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526925986290928,"score_gpt":0.2249665631900717,"score_spread":0.2096973033271624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}