{"id":"W2428071229","doi":"10.1038/srep20127","title":"Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lee Kong Chian School of Medicine, Nanyang Technological University; Conseil Régional Midi-Pyrénées; Université de Lausanne; Karolinska Institutet; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Nanyang Technological University; Medical Research Council; Canadian Institute for Advanced Research; Agence Nationale de la Recherche; National Science Foundation","keywords":"Biology; Nuclear receptor; Microbiome; Metabolome; Circadian clock; Gene expression; Circadian rhythm; Liver X receptor; Regulation of gene expression; Cell biology; Effector; Crosstalk; Pregnane X receptor; Lipid metabolism; Transcriptome; Endocrinology; Transcription factor; Gene; Biochemistry; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000747,0.0002405,0.0002627176,0.0002534989,0.0001646409,0.000474562,0.0001413973,0.0001551796,0.000936099],"category_scores_gemma":[0.0002163639,0.0001139778,0.0002685991,0.000126378,0.0002910586,0.000249939,0.0003843677,0.0003003786,0.0002196336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002995312,"about_ca_system_score_gemma":0.00029647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006131486,"about_ca_topic_score_gemma":0.001293555,"domain_scores_codex":[0.9998121,0.00003666349,0.00001111542,0.00004807482,0.00004443049,0.00004773137],"domain_scores_gemma":[0.9998159,0.0000134356,0.00007516385,0.00002616975,0.00003030951,0.00003908157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000486011,0.00001633844,0.003232069,0.00005716931,0.0000199134,0.0001065058,0.00005431452,0.00009844135,0.9870496,0.0006879281,0.0001419401,0.008049865],"study_design_scores_gemma":[0.00009246494,0.000839713,0.1975505,0.0000855621,0.0001353987,0.0008580217,0.0004386229,0.002679899,0.7733499,0.001887884,0.02202921,0.00005284899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623219,0.009176669,0.02268045,0.0004891427,0.0002257264,0.00003070311,0.0006901585,0.0002908253,0.004094371],"genre_scores_gemma":[0.9884952,0.002403798,0.005562555,0.0001197022,0.00006023711,0.00003041388,0.0003841202,0.00004207282,0.002901993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000936099,"threshold_uncertainty_score":0.003131509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526925986290928,"score_gpt":0.2249665631900717,"score_spread":0.2096973033271624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}