{"id":"W2428522048","doi":"10.1002/stem.2426","title":"COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis","year":2016,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; University of Alberta","funders":"","keywords":"Biology; Wnt signaling pathway; Cancer research; CD44; PI3K/AKT/mTOR pathway; Stem cell; Protein kinase B; Cancer stem cell; HES1; Notch signaling pathway; Molecular biology; Cell biology; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006896375,0.0001861702,0.0001087467,0.0001828536,0.00008657845,0.0001985074,0.00006458999,0.0001170549,0.00163698],"category_scores_gemma":[0.00003781817,0.0000847825,0.0002027071,0.0001060056,0.00008445835,0.00009478212,0.0001149208,0.0004054648,0.0003001155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946488,"about_ca_system_score_gemma":0.0001631987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004692336,"about_ca_topic_score_gemma":0.001064158,"domain_scores_codex":[0.999947,0.000007254609,0.000003424875,0.000008417397,0.00001767369,0.00001625483],"domain_scores_gemma":[0.9999737,0.000002855837,0.000007451961,0.000002693373,0.000004314202,0.000008951944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002610724,0.00007096287,0.0007696261,0.00006853567,0.000009319308,0.0001119388,0.00001433632,0.00005550907,0.9956546,0.0001933374,0.0001789845,0.002611655],"study_design_scores_gemma":[0.00005447108,0.0004546507,0.01644142,0.000009155373,0.0000329609,0.0002641197,0.00005005904,0.0009631659,0.9759672,0.0001049572,0.005654482,0.000003474676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990915,0.002210429,0.001895779,0.000191371,0.00004610054,0.00004656564,0.0008989594,0.0000907285,0.003704972],"genre_scores_gemma":[0.9887502,0.001711395,0.001243739,0.00009221843,0.00001394437,0.00005115605,0.001270044,0.000009742041,0.006857629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00163698,"threshold_uncertainty_score":0.005476236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477966930631512,"score_gpt":0.2463237888277354,"score_spread":0.2315441195214203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}