{"id":"W2428522048","doi":"10.1002/stem.2426","title":"COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis","year":2016,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; University of Alberta","funders":"","keywords":"Biology; Wnt signaling pathway; Cancer research; CD44; PI3K/AKT/mTOR pathway; Stem cell; Protein kinase B; Cancer stem cell; HES1; Notch signaling pathway; Molecular biology; Cell biology; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003402065,0.0004802247,0.0008135195,0.0001984023,0.0001554691,0.00005261332,0.0003307425,0.0002845314,0.001545744],"category_scores_gemma":[0.000003410764,0.0003269399,0.0003027103,0.0003051147,0.0003027543,0.0002054228,0.00009030368,0.0002631749,0.001122877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004115128,"about_ca_system_score_gemma":0.0004807491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008883995,"about_ca_topic_score_gemma":0.00008924289,"domain_scores_codex":[0.9970868,0.000185941,0.0006257283,0.0006905848,0.000609471,0.0008014465],"domain_scores_gemma":[0.9980094,0.0002532014,0.0002851773,0.0008412034,0.000226352,0.0003846573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001719326,0.0002440344,0.001323703,0.0003342766,0.0002075361,0.0001526828,0.0008714127,0.000003808134,0.6744662,0.00002697972,0.01594879,0.3047012],"study_design_scores_gemma":[0.003012536,0.0003887811,0.004884475,0.001146462,0.0002042785,0.0002651468,0.0006924327,0.00001405194,0.8077785,0.00001239375,0.1810346,0.0005662607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821967,0.007529305,0.0001127073,0.003726962,0.002309055,0.0009819024,0.0002541756,0.0002161936,0.002673007],"genre_scores_gemma":[0.9455827,0.002539454,0.00002747136,0.0005735183,0.001292851,0.00009037542,0.000004236054,0.000103281,0.04978614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.304135,"threshold_uncertainty_score":0.9999183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477966930631512,"score_gpt":0.2463237888277354,"score_spread":0.2315441195214203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}