{"id":"W2431537761","doi":"10.1080/17460441.2016.1196183","title":"Simple animal models for amyotrophic lateral sclerosis drug discovery","year":2016,"lang":"en","type":"review","venue":"Expert Opinion on Drug Discovery","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Institut National de la Recherche Scientifique; St. Michael's Hospital; Université de Montréal; Armand Frappier Museum","funders":"","keywords":"Drug discovery; Amyotrophic lateral sclerosis; Zebrafish; Chemical genetics; Computational biology; Biology; Neuroscience; Model organism; Computer science; Disease; Bioinformatics; Medicine; Genetics; Small molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008532034,0.0008069755,0.001129953,0.002191647,0.0002304138,0.000927593,0.001044463,0.001409559,0.005785337],"category_scores_gemma":[0.0007219345,0.0002513868,0.0006586008,0.001075059,0.0005653972,0.001270861,0.0006728484,0.002212756,0.003895737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006079798,"about_ca_system_score_gemma":0.0008605451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007033106,"about_ca_topic_score_gemma":0.001572093,"domain_scores_codex":[0.9996729,0.00005761347,0.00004023319,0.00004540399,0.000159358,0.0000244479],"domain_scores_gemma":[0.9995829,0.0001570531,0.00007899578,0.00001595991,0.000124984,0.00004004339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009352397,0.00008413374,0.0001664044,0.02337798,0.000116729,0.0003509598,0.00007019033,0.0003464424,0.007478159,0.01037746,0.06386878,0.8936692],"study_design_scores_gemma":[0.00001850469,0.0000925733,0.0002972877,0.003488947,0.00008088877,0.0008566813,0.00002675719,0.00006647722,0.0009192997,0.002379688,0.9917566,0.00001637621],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001839751,0.994575,0.0005762218,0.0009285601,0.0005161723,0.00002494251,0.00006773297,0.0000304025,0.003097069],"genre_scores_gemma":[0.00111489,0.996051,0.0006300153,0.0006015379,0.0002077418,0.00002195579,0.00009481714,0.000003713608,0.00127433],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005785337,"threshold_uncertainty_score":0.01935393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.105502348276002,"score_gpt":0.3801763797733106,"score_spread":0.2746740314973086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}