{"id":"W2432277981","doi":"10.1038/ncomms11843","title":"Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Alberta Health Services; Provincial Laboratory of Public Health; Lunenfeld-Tanenbaum Research Institute; University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute for Occupational Safety and Health; U.S. National Library of Medicine; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; National Research Foundation of Korea; Medical Research Council; University of Texas MD Anderson Cancer Center; National Key Research and Development Program of China; National Science Council; Korea Health Industry Development Institute; Natural Science Foundation of Guangdong Province; Government of Jiangsu Province; National Natural Science Foundation of China; National High-tech Research and Development Program; Agency for Science, Technology and Research; National Institute on Aging; National Institute for Health and Care Research; Ministry of Science, ICT and Future Planning; China Medical Board; Women's Health Initiative; National Medical Research Council; Program for Changjiang Scholars and Innovative Research Team in University; National Research Foundation; World Health Organization; Cancer Research UK; State of Connecticut Department of Public Health; National Research Program for Biopharmaceuticals; National Institutes of Health; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Genetics; X chromosome; X-inactivation; Chromosome; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003700425,0.0001422294,0.0002149908,0.0007724922,0.0001737569,0.000193943,0.0001019889,0.0001389147,0.002019312],"category_scores_gemma":[0.001020916,0.00009351224,0.0001434153,0.0004543343,0.0002017111,0.0001090753,0.0001642329,0.0001197469,0.0001412686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007269187,"about_ca_system_score_gemma":0.00007589998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000778862,"about_ca_topic_score_gemma":0.001025753,"domain_scores_codex":[0.9997798,0.00004965825,0.00001482403,0.00007975378,0.00004427678,0.00003170892],"domain_scores_gemma":[0.9994816,0.0001569032,0.0002388393,0.0000492448,0.00003456844,0.00003875992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002839344,0.00001029152,0.9447982,0.00002306505,0.0000710058,0.0004962398,0.0001426234,0.00004585576,0.04790486,0.00008262142,0.00008921279,0.006052118],"study_design_scores_gemma":[0.000002477072,0.00007231504,0.994572,0.000001782797,0.00001760295,0.001653128,0.00003597376,0.00006375527,0.003203707,0.00005442719,0.0003207383,0.000002133717],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984077,0.0005147695,0.0004699287,0.00001796437,0.000003152678,0.000003945146,0.000179003,0.000007386616,0.0003962989],"genre_scores_gemma":[0.9994884,0.000123442,0.000119408,0.000006932419,0.000004457011,0.000001606674,0.00008475996,0.000002255679,0.0001687026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002019312,"threshold_uncertainty_score":0.006755292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540157145804571,"score_gpt":0.2796494155684324,"score_spread":0.2642478441103867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}