{"id":"W2432277981","doi":"10.1038/ncomms11843","title":"Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Alberta Health Services; Provincial Laboratory of Public Health; Lunenfeld-Tanenbaum Research Institute; University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute for Occupational Safety and Health; U.S. National Library of Medicine; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; National Research Foundation of Korea; Medical Research Council; University of Texas MD Anderson Cancer Center; National Key Research and Development Program of China; National Science Council; Korea Health Industry Development Institute; Natural Science Foundation of Guangdong Province; Government of Jiangsu Province; National Natural Science Foundation of China; National High-tech Research and Development Program; Agency for Science, Technology and Research; National Institute on Aging; National Institute for Health and Care Research; Ministry of Science, ICT and Future Planning; China Medical Board; Women's Health Initiative; National Medical Research Council; Program for Changjiang Scholars and Innovative Research Team in University; National Research Foundation; World Health Organization; Cancer Research UK; State of Connecticut Department of Public Health; National Research Program for Biopharmaceuticals; National Institutes of Health; U.S. Department of Health and Human Services; National Science Foundation","keywords":"Genetics; X chromosome; X-inactivation; Chromosome; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540728,0.000179338,0.0001578074,0.00003138208,0.0003320508,0.00005027622,0.000791426,0.0003995619,0.0001069105],"category_scores_gemma":[0.0001420024,0.0001056507,0.00008921039,0.0001227235,0.0005394574,0.00001234067,0.0005268194,0.0003329694,0.00002691636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001418072,"about_ca_system_score_gemma":0.00004911443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005940795,"about_ca_topic_score_gemma":0.00007856727,"domain_scores_codex":[0.9989527,0.0001555506,0.0002383342,0.0002939109,0.0001491475,0.000210369],"domain_scores_gemma":[0.998282,0.0001375444,0.0001235723,0.001250335,0.0001141551,0.00009245724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000929036,0.0005088098,0.00447052,0.00004344868,0.0004549893,0.000006022358,0.0008670329,0.000001225003,0.9294136,0.02067406,0.01328355,0.03018387],"study_design_scores_gemma":[0.003135991,0.0008892462,0.06996584,0.0002007809,0.0001684393,0.00009469972,0.0007330916,0.00004475418,0.3877858,0.003569829,0.5324499,0.0009616265],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783973,0.004336813,0.00002892722,0.01050728,0.000151274,0.0002960937,0.00005820049,0.00004290809,0.00618126],"genre_scores_gemma":[0.990478,0.003206031,0.0002117797,0.001207519,0.00008279366,0.0000489319,0.0001019519,0.00002057861,0.004642448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5416278,"threshold_uncertainty_score":0.4308311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540157145804571,"score_gpt":0.2796494155684324,"score_spread":0.2642478441103867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}