{"id":"W2432987008","doi":"10.1186/s13054-016-1374-6","title":"Genomics and pharmacogenomics of sepsis: so close and yet so far","year":2016,"lang":"en","type":"letter","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Pharmacogenomics; Medicine; Sepsis; Intensive care medicine; Pharmacogenetics; Biomarker; Bioinformatics; Procalcitonin; Precision medicine; Pharmacology; Internal medicine; Gene; Biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000518888,0.0003082924,0.0006537006,0.00009014762,0.00008562095,0.00004931369,0.0000700896,0.0004777932,0.0001589188],"category_scores_gemma":[0.0001211612,0.0002306489,0.0001456453,0.00003071916,0.0005608574,0.00003061526,0.0001031713,0.000440248,0.00001994189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338521,"about_ca_system_score_gemma":0.0001525828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002165285,"about_ca_topic_score_gemma":0.000002394949,"domain_scores_codex":[0.9986234,0.00004231309,0.0003038736,0.0004756351,0.0002029115,0.0003518796],"domain_scores_gemma":[0.9988105,0.0004327758,0.00004816373,0.0003162054,0.0002029708,0.0001894006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001479458,0.0001911485,0.01245007,0.006952026,0.000820117,0.00252251,0.001753857,4.671001e-8,0.001566535,0.0009374067,0.8892326,0.08342575],"study_design_scores_gemma":[0.001684038,0.0003440388,0.001076698,0.0004273036,0.001780358,0.0001106226,0.0002819368,0.000002862409,0.002597036,0.0004019426,0.9910095,0.0002837176],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1885272,0.09440854,0.00001164426,0.7122825,0.0006175893,0.0007997957,0.002088403,0.00005623357,0.001208093],"genre_scores_gemma":[0.263833,0.009885247,0.0008218916,0.7213489,0.003185855,0.00009777689,0.0004678227,0.0001504093,0.0002091784],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1017769,"threshold_uncertainty_score":0.9405588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06441141351878829,"score_gpt":0.3654580768087866,"score_spread":0.3010466632899983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}