{"id":"W2432987008","doi":"10.1186/s13054-016-1374-6","title":"Genomics and pharmacogenomics of sepsis: so close and yet so far","year":2016,"lang":"en","type":"letter","venue":"Critical Care","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Pharmacogenomics; Medicine; Sepsis; Intensive care medicine; Pharmacogenetics; Biomarker; Bioinformatics; Procalcitonin; Precision medicine; Pharmacology; Internal medicine; Gene; Biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007706334,0.001114649,0.002196446,0.0008277809,0.002689396,0.004576451,0.001524397,0.02617175,0.003127138],"category_scores_gemma":[0.03245437,0.0006371824,0.001179971,0.0008790608,0.005515917,0.009074809,0.002662306,0.03496143,0.002845736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002443131,"about_ca_system_score_gemma":0.002715338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511549,"about_ca_topic_score_gemma":0.002043621,"domain_scores_codex":[0.9945993,0.002354739,0.0006240473,0.0006196553,0.001431711,0.0003705447],"domain_scores_gemma":[0.9702761,0.01956023,0.001314889,0.001214555,0.004762423,0.00287183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001773209,0.0001544038,0.0019938,0.0003536805,0.00008699315,0.003960577,0.0003363882,0.0002564476,0.000519748,0.008913461,0.8872064,0.09604074],"study_design_scores_gemma":[0.0002375109,0.0002183258,0.001837143,0.0009261697,0.00008540203,0.008553331,0.001012697,0.001033568,0.0005420024,0.06893084,0.9164811,0.0001419159],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002394634,0.008363532,0.000211109,0.9804251,0.01021479,0.000004236511,0.00001301753,0.00002010503,0.0005087466],"genre_scores_gemma":[0.005363465,0.01762863,0.0008483215,0.8498416,0.1243648,0.00002161969,0.00002391792,0.00002348026,0.001884146],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02617175,"threshold_uncertainty_score":0.04075545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06441141351878829,"score_gpt":0.3654580768087866,"score_spread":0.3010466632899983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}