{"id":"W2433258312","doi":"10.1016/j.bpj.2015.11.1268","title":"Understanding Structural and Functional Stability of two Rhomboid Proteases: HiGlpG and PsAarA","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Alberta","funders":"","keywords":"Proteases; Rhomboid; Chemistry; Guanidinium chloride; Circular dichroism; Native state; Dimer; Globular protein; Denaturation (fissile materials); Biophysics; Protein folding; Crystallography; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003783119,0.0002579912,0.0002413642,0.0001800567,0.0001865233,0.0006028831,0.0006055396,0.0005061687,0.0006635955],"category_scores_gemma":[0.0006835408,0.0001948328,0.0002426353,0.0001292247,0.0004035193,0.0006219708,0.0002155736,0.001218695,0.0002316202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006018594,"about_ca_system_score_gemma":0.0002758077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007241212,"about_ca_topic_score_gemma":0.0004862791,"domain_scores_codex":[0.9998455,0.00002303033,0.00001138427,0.00003254161,0.00005288559,0.00003452988],"domain_scores_gemma":[0.9997939,0.0000666627,0.00005239571,0.00002249968,0.00003693044,0.0000274682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009152322,0.0000169248,0.000772056,0.00002700552,0.00000965732,0.00007111383,0.00003937618,0.0004411051,0.9959702,0.0005865754,0.00005058018,0.001923961],"study_design_scores_gemma":[0.00001199644,0.00007128758,0.005357724,0.000003533152,0.00001712732,0.0003558751,0.00007969446,0.0103854,0.9820197,0.0004402445,0.001247914,0.000009556575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942438,0.0008496122,0.004242994,0.0002232317,0.000009523811,0.000006008036,0.00007727117,0.00003661052,0.0003110226],"genre_scores_gemma":[0.9977595,0.000247398,0.001387934,0.00004365015,0.000005177795,0.000006523175,0.0002164844,0.0000124197,0.0003209486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007241212,"threshold_uncertainty_score":0.004366815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03929135718565339,"score_gpt":0.2670600370108359,"score_spread":0.2277686798251825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}