{"id":"W2433847111","doi":"10.1093/neuonc/now073.49","title":"HG-53HYPERMUTATION AND NEOANTIGEN FORMATION PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION IN CHILDHOOD BIALLELIC MISMATCH REPAIR DEFICIENT GLIOBLASTOMA","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; Izaak Walton Killam Health Centre; University of Manitoba; Mount Sinai Hospital; CancerCare Manitoba; Research Institute in Oncology and Hematology; SickKids Foundation; Université Laval; Hospital for Sick Children","funders":"","keywords":"Glioblastoma; DNA mismatch repair; Immune system; Medicine; Cancer research; DNA repair; Immunology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878683,0.0001941015,0.0002442985,0.0005247796,0.000115705,0.0002655577,0.0001231737,0.0002435963,0.0008590422],"category_scores_gemma":[0.001093356,0.0001424672,0.0001445275,0.0004003916,0.0001747067,0.0001675842,0.0002202373,0.0001952446,0.0001869377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415989,"about_ca_system_score_gemma":0.0001581568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003198048,"about_ca_topic_score_gemma":0.004123816,"domain_scores_codex":[0.9998679,0.00002350792,0.00001686624,0.00002793003,0.00002883128,0.00003482907],"domain_scores_gemma":[0.9995075,0.000111801,0.0002387494,0.00001912865,0.00003648395,0.00008623427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003667498,0.00002239281,0.9848396,0.00001224325,0.00002023973,0.0004233086,0.00006178362,0.0002858881,0.008697015,0.00002019727,0.00008915884,0.00516145],"study_design_scores_gemma":[0.000003543168,0.0001166241,0.99602,0.000003472948,0.00001409529,0.001370452,0.00006267809,0.0004396853,0.00182427,0.00001759106,0.0001251218,0.000002428224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996765,0.0000997425,0.00005394021,0.000005663427,5.585446e-7,0.000001533772,0.00005397222,0.000003935494,0.0001040981],"genre_scores_gemma":[0.9996506,0.00005591062,0.00009627949,0.000006049333,6.191852e-7,0.000001976071,0.0001351363,0.000002248413,0.00005128514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003198048,"threshold_uncertainty_score":0.006358862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615819160788658,"score_gpt":0.2998680927215731,"score_spread":0.2837099011136865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}