{"id":"W2434067783","doi":"10.1534/g3.116.027805","title":"UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in<i>Caenorhabditis elegans</i>","year":2016,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Institute for Advanced Research; National Institutes of Health; Syracuse University","keywords":"Ubiquitin ligase; Notch signaling pathway; Biology; Caenorhabditis elegans; Cell biology; Genetic screen; Hes3 signaling axis; Genetics; Transcription factor; Germline; Drosophila melanogaster; Enhancer; Signal transduction; Mutation; Loss function; Ubiquitin; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007419706,0.0005411477,0.0001755048,0.000281507,0.0003022098,0.0002968017,0.0002837756,0.0002704477,0.000749883],"category_scores_gemma":[0.00005491901,0.0001676587,0.0002898738,0.00008795223,0.0002407126,0.0001306191,0.0002415283,0.0002649159,0.0005035124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006182657,"about_ca_system_score_gemma":0.0002652983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002304075,"about_ca_topic_score_gemma":0.00539536,"domain_scores_codex":[0.9998845,0.000007470252,0.000009620669,0.0000361299,0.00003647235,0.00002571331],"domain_scores_gemma":[0.9999553,0.000002763301,0.00001622641,0.000004376977,0.000005068964,0.00001618406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005117014,0.000009583834,0.0006633443,0.00003371329,0.000004320629,0.0001151262,0.000006235588,0.00007669908,0.9972691,0.000102255,0.0001214426,0.001547073],"study_design_scores_gemma":[0.00002014041,0.00009674573,0.03066357,0.00002028692,0.00003380445,0.0008730106,0.00003864664,0.00208878,0.9584203,0.00009623804,0.007635506,0.00001306384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986937,0.003547401,0.004324608,0.0001227068,0.00004972768,0.00003077068,0.001128702,0.0003583172,0.003500794],"genre_scores_gemma":[0.9919094,0.0006774559,0.002295082,0.00008365595,0.000005405468,0.00001488977,0.001131592,0.00002511798,0.003857384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304075,"threshold_uncertainty_score":0.004581332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015840048774966,"score_gpt":0.2345879167543412,"score_spread":0.2187478679793752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}