{"id":"W2434067783","doi":"10.1534/g3.116.027805","title":"UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in<i>Caenorhabditis elegans</i>","year":2016,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Institute for Advanced Research; National Institutes of Health; Syracuse University","keywords":"Ubiquitin ligase; Notch signaling pathway; Biology; Caenorhabditis elegans; Cell biology; Genetic screen; Hes3 signaling axis; Genetics; Transcription factor; Germline; Drosophila melanogaster; Enhancer; Signal transduction; Mutation; Loss function; Ubiquitin; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000438592,0.0006660844,0.0005840063,0.0002011604,0.0002176037,0.000107705,0.0007823564,0.00043055,0.0001540478],"category_scores_gemma":[0.00006465893,0.0006065954,0.0002031484,0.0004354993,0.0003883854,0.00001463562,0.0004196075,0.0001951969,0.0001316766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008484792,"about_ca_system_score_gemma":0.0004440826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007894847,"about_ca_topic_score_gemma":0.000516352,"domain_scores_codex":[0.9962609,0.0002506222,0.0008353522,0.00116016,0.0004052557,0.001087683],"domain_scores_gemma":[0.9976571,0.00009112931,0.0003097541,0.001087706,0.0005281643,0.0003261419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494577,0.0001062487,0.01554001,0.00005653753,0.0001230207,0.0000273661,0.0004688133,0.001070953,0.9170814,0.00003025822,0.0008526217,0.0644933],"study_design_scores_gemma":[0.001338287,0.0007234946,0.003226942,0.00006711311,0.00007251841,0.00005251409,0.0001667602,0.00009454868,0.8802282,0.0005539622,0.1126052,0.000870398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8667123,0.1300314,0.001149293,0.0005036854,0.000689052,0.0005204129,0.00008067406,0.00006388484,0.0002493213],"genre_scores_gemma":[0.9283286,0.06211354,0.00544565,0.0008818225,0.0007948112,0.00002921311,0.0001420264,0.0001609886,0.002103396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1117526,"threshold_uncertainty_score":0.9996386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015840048774966,"score_gpt":0.2345879167543412,"score_spread":0.2187478679793752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}