{"id":"W2434085253","doi":"10.1038/srep27791","title":"Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"European Regional Development Fund; Fundação para a Ciência e a Tecnologia; European Commission","keywords":"Mesenchymal stem cell; Cell biology; Bioreactor; Modulation (music); Cell; Cell growth; Cellular differentiation; Biology; Gene; Biochemistry; Botany; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005197287,0.0002085505,0.0002762342,0.0001768301,0.0003515831,0.0002021058,0.0001434272,0.00005245419,0.00002018254],"category_scores_gemma":[0.00009850164,0.0001073812,0.0001543505,0.0003496031,0.0001511414,0.0002431997,0.0001060853,0.00007498305,0.000002614574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003831933,"about_ca_system_score_gemma":0.0001049651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003913885,"about_ca_topic_score_gemma":0.000001241673,"domain_scores_codex":[0.9971856,0.0003916564,0.0005556248,0.0007850359,0.0008346734,0.0002473978],"domain_scores_gemma":[0.9982539,0.0002983377,0.0007046185,0.0005287043,0.0001134156,0.0001010598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006841863,0.0001155654,0.005587087,0.0000121228,0.000002116465,0.00001208111,0.000046737,0.0006286984,0.993234,0.00008034592,0.00001872741,0.0001941019],"study_design_scores_gemma":[0.0006677933,0.0001251912,0.02343687,0.00002449245,0.00001905528,0.00004061004,0.000003236409,0.02258953,0.9527854,0.0001859246,0.000008374464,0.0001135491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913649,0.000002650737,0.003153688,0.00003342859,0.004741283,0.0006183567,0.00001470376,0.0000331382,0.00003786285],"genre_scores_gemma":[0.9996335,0.000001373846,0.00002190834,0.00001766705,0.00008032355,0.000006078556,0.000001838651,0.0000201374,0.0002171733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04044862,"threshold_uncertainty_score":0.4378877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02743126203726106,"score_gpt":0.2412972640633344,"score_spread":0.2138660020260733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}