{"id":"W2434582744","doi":"10.1182/blood.v122.21.1638.1638","title":"TP53 Mutation or Deletion and Efficacy with Single-Agent Lenalidomide in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) (CC-5013-CLL-009 Study)","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Lenalidomide; Medicine; Internal medicine; Neutropenia; Bendamustine; Chronic lymphocytic leukemia; Oncology; Gastroenterology; Refractory (planetary science); Febrile neutropenia; Chemotherapy; Leukemia; Multiple myeloma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005476603,0.0004206799,0.0006612049,0.0004214185,0.0001344752,0.0001174926,0.0002056296,0.000237839,0.0003257647],"category_scores_gemma":[0.000728359,0.0002848059,0.00006637823,0.0007576746,0.0001728626,0.0002451033,0.0001244968,0.0004249289,0.0002362639],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.04982822,"about_ca_system_score_gemma":0.02084538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004327802,"about_ca_topic_score_gemma":0.002142305,"domain_scores_codex":[0.9964678,0.0002529658,0.0007308922,0.0008264907,0.0009403021,0.0007815435],"domain_scores_gemma":[0.9978525,0.000586416,0.0002241235,0.0007473279,0.0002240202,0.000365614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1129919,0.119193,0.02245046,0.01373614,0.008788346,0.07088039,0.0462745,0.008402033,0.2358263,0.0002379731,0.009518133,0.3517008],"study_design_scores_gemma":[0.8806182,0.0210969,0.03240903,0.002121754,0.001331605,0.004631143,0.002954491,0.03352723,0.01861103,0.00003970667,0.001439968,0.001218911],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950781,0.000749978,0.00003855352,0.0001143596,0.00007983598,0.003250233,0.000002478754,0.0001541275,0.0005323554],"genre_scores_gemma":[0.9966873,0.0001691717,0.0004897499,0.0001787206,0.0002639654,0.0003506421,0.00003483813,0.0001045582,0.001721067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7676263,"threshold_uncertainty_score":0.9999604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886515541554497,"score_gpt":0.2854078378169268,"score_spread":0.2565426824013818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}