{"id":"W2435490795","doi":"10.1200/jco.2014.32.15_suppl.2530","title":"A phase 1b study of the cancer stem cell inhibitor BBI608 administered with paclitaxel in patients with advanced malignancies.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Adverse effect; Nausea; Gastroenterology; Cancer; Vomiting; Paclitaxel; Oncology; Discontinuation; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215616,0.001687645,0.00252885,0.0007510297,0.0004631319,0.0009871883,0.0009229625,0.001437059,0.004903009],"category_scores_gemma":[0.0006236656,0.0008265108,0.00109552,0.0007371619,0.0008009737,0.0007034185,0.0003973114,0.003462875,0.00149274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001030985,"about_ca_system_score_gemma":0.002112725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001471733,"about_ca_topic_score_gemma":0.002764398,"domain_scores_codex":[0.9995849,0.0001542648,0.00002586325,0.00008646032,0.00005904533,0.00008952618],"domain_scores_gemma":[0.9994859,0.00005516137,0.0001136301,0.00003758243,0.00004437272,0.0002634404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5453492,0.1489787,0.008115347,0.001673724,0.001517765,0.0005676785,0.0003788941,0.003109999,0.1167774,0.0004385122,0.009118268,0.1639745],"study_design_scores_gemma":[0.4965591,0.4790467,0.01056191,0.00005210608,0.0004385164,0.0003976617,0.00004722428,0.001119561,0.006655355,0.0001765808,0.004917616,0.00002760575],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797078,0.004270573,0.001105206,0.0008941056,0.0002493197,0.007262923,0.002249913,0.000230001,0.004030114],"genre_scores_gemma":[0.9746572,0.004331646,0.003365406,0.001575653,0.0002693217,0.005664432,0.00528836,0.0000676953,0.004780243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004903009,"threshold_uncertainty_score":0.01640224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1198735205547912,"score_gpt":0.4955037543018407,"score_spread":0.3756302337470495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}