{"id":"W2435850291","doi":"10.1016/s2468-1253(16)30001-2","title":"Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial","year":2016,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"AbbVie","keywords":"Ribavirin; Ritonavir; Medicine; Ombitasvir; Paritaprevir; Cirrhosis; Virology; Open label; Internal medicine; Hepatitis C virus; Hepatitis C; Gastroenterology; Human immunodeficiency virus (HIV); Randomized controlled trial; Virus; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00183662,0.002441769,0.003264258,0.0004217208,0.0003690805,0.001279036,0.00107665,0.002145291,0.005817466],"category_scores_gemma":[0.001666825,0.0008633556,0.002389974,0.0004920925,0.001142912,0.001601699,0.0006852419,0.003691236,0.001285844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007737841,"about_ca_system_score_gemma":0.0008572972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008618741,"about_ca_topic_score_gemma":0.001882149,"domain_scores_codex":[0.9991773,0.0004722284,0.0000494338,0.0001093061,0.00004892012,0.0001428195],"domain_scores_gemma":[0.9993358,0.0002014306,0.0001486137,0.00005338514,0.00003681273,0.0002239711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98177,0.002243904,0.0004297065,0.000654447,0.001041654,0.00004177542,0.00005709081,0.0002153701,0.001596175,0.0000979613,0.0005315061,0.01132052],"study_design_scores_gemma":[0.9692109,0.02856412,0.0009541609,0.00003734492,0.0004209269,0.00003348995,0.00002541568,0.0001725639,0.000141866,0.0001021673,0.0003250655,0.0000119094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830527,0.009722888,0.0005119582,0.0009454402,0.0006300332,0.00200898,0.0007947003,0.0001561234,0.002177153],"genre_scores_gemma":[0.9844595,0.005250442,0.001679117,0.001393997,0.00055687,0.002881753,0.001140146,0.00003349572,0.002604774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005817466,"threshold_uncertainty_score":0.01946139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04196157814196336,"score_gpt":0.3391781416447672,"score_spread":0.2972165635028039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}