{"id":"W2436107268","doi":"10.18433/j3w904","title":"Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update","year":2016,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Supersaturation; Bioavailability; Drug delivery; Drug; Chemistry; Solubility; Nanotechnology; Biochemical engineering; Mechanism (biology); Pharmacology; Materials science; Medicine; Engineering; Physics; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01419292,0.0009123774,0.001709985,0.0004341912,0.001312889,0.0005504243,0.002346919,0.0004485893,0.003538392],"category_scores_gemma":[0.0001827986,0.0004314696,0.001240667,0.000523243,0.001285611,0.001398809,0.0001713044,0.001928037,0.0002533711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004373512,"about_ca_system_score_gemma":0.001779897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000172118,"about_ca_topic_score_gemma":0.000003796749,"domain_scores_codex":[0.9912128,0.003005778,0.00228142,0.0009115055,0.001240286,0.001348136],"domain_scores_gemma":[0.9940149,0.002928547,0.001190509,0.0004335658,0.0005953303,0.0008371243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001369721,0.001316873,0.000006010743,0.004006556,0.000621194,0.00003764248,0.0005631401,0.0001751807,0.003978844,0.009635217,0.00581474,0.9724749],"study_design_scores_gemma":[0.00217751,0.001029825,1.15939e-7,0.000871177,0.001303341,0.00005286383,0.0004144196,0.01033826,0.009215905,0.001585098,0.9723932,0.0006183616],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003706891,0.9533061,0.002446123,0.01359746,0.01695283,0.006620965,0.0007998689,0.0001855556,0.002384143],"genre_scores_gemma":[0.06742797,0.923085,0.0002476327,0.006139301,0.002442061,0.0002895269,0.00004583324,0.00008210887,0.0002405831],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9718565,"threshold_uncertainty_score":0.9999872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.247873733773536,"score_gpt":0.4957336111994576,"score_spread":0.2478598774259216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}