{"id":"W2437385547","doi":"10.1172/jci.insight.85971","title":"Asfotase alfa therapy for children with hypophosphatasia","year":2016,"lang":"en","type":"article","venue":"JCI Insight","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Winnipeg; University of Manitoba; Manitoba Health","funders":"Shriners Hospitals for Children; University of Manitoba; Alexion Pharmaceuticals","keywords":"Hypophosphatasia; Rickets; Medicine; Alkaline phosphatase; Internal medicine; Endocrinology; Genetic enhancement; Chemistry; Biochemistry; Vitamin D and neurology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152773,0.0002218276,0.0003438544,0.00008493313,0.0001406251,0.0000115834,0.0001258968,0.00006126471,0.0001782875],"category_scores_gemma":[0.0001714428,0.0001046269,0.00009677248,0.0001865818,0.000191044,0.0001002865,0.00005301528,0.0000963204,0.0001242422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000755529,"about_ca_system_score_gemma":0.0001563906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003830885,"about_ca_topic_score_gemma":0.00001061953,"domain_scores_codex":[0.9985702,0.00002199337,0.0001952039,0.0003767068,0.0003913883,0.0004444789],"domain_scores_gemma":[0.9988466,0.0001810793,0.00006672162,0.0004842904,0.0002066034,0.0002146854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006942205,0.001386483,0.09879771,0.000100491,0.002531349,0.0002004781,0.0004616315,5.975093e-7,0.009099182,0.004380906,0.236912,0.6391869],"study_design_scores_gemma":[0.02372397,0.00426062,0.3270127,0.0003382103,0.0001769168,0.0001613388,0.00004911483,0.000008222029,0.1576788,0.001708165,0.4842764,0.0006056668],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8949876,0.07262764,0.001318413,0.02184082,0.0002077143,0.005270012,0.001175794,0.0003559591,0.002216037],"genre_scores_gemma":[0.9818661,0.008259146,0.003361419,0.001662936,0.0007488303,0.0006034353,0.0002772145,0.0001076295,0.003113347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6385813,"threshold_uncertainty_score":0.4266562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02792130568054027,"score_gpt":0.3084529168910247,"score_spread":0.2805316112104844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}