{"id":"W2437385547","doi":"10.1172/jci.insight.85971","title":"Asfotase alfa therapy for children with hypophosphatasia","year":2016,"lang":"en","type":"article","venue":"JCI Insight","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Winnipeg; University of Manitoba; Manitoba Health","funders":"Shriners Hospitals for Children; University of Manitoba; Alexion Pharmaceuticals","keywords":"Hypophosphatasia; Rickets; Medicine; Alkaline phosphatase; Internal medicine; Endocrinology; Genetic enhancement; Chemistry; Biochemistry; Vitamin D and neurology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002913142,0.0003837733,0.0006656563,0.0002664385,0.0002986365,0.0001547665,0.0001993952,0.00033189,0.0009479428],"category_scores_gemma":[0.0003896579,0.00006062971,0.0004184684,0.000203009,0.000207217,0.0001582934,0.0001346816,0.0006602294,0.0001996246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004725003,"about_ca_system_score_gemma":0.0003997846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000905733,"about_ca_topic_score_gemma":0.001964794,"domain_scores_codex":[0.9998074,0.00005143525,0.00002549979,0.00002337496,0.00005185779,0.00004042311],"domain_scores_gemma":[0.9997424,0.00004924545,0.00008872866,0.000008679266,0.00003444798,0.00007643908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02711613,0.004346894,0.2291548,0.002924516,0.0008455108,0.01370236,0.0009883954,0.001433092,0.07204042,0.001187481,0.01236514,0.6338953],"study_design_scores_gemma":[0.00683165,0.1058803,0.6147963,0.0009714825,0.001217837,0.1049334,0.000862551,0.002053407,0.04890467,0.0005910535,0.1128822,0.00007512912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477155,0.04667264,0.0007164638,0.0006843972,0.000135348,0.0001000153,0.0002276959,0.00008658128,0.003661353],"genre_scores_gemma":[0.9886663,0.008355979,0.001318575,0.00039435,0.00008425629,0.00005746832,0.0003348185,0.000007233915,0.000780972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009479428,"threshold_uncertainty_score":0.003428221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02792130568054027,"score_gpt":0.3084529168910247,"score_spread":0.2805316112104844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}