{"id":"W2437481494","doi":"10.1371/journal.pone.0157265","title":"Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; University of Saskatchewan","funders":"University of South China; Construct Program of the Key Discipline in Hunan Province; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"ABCA1; DNA methylation; DNA methyltransferase; DNMT1; Gene knockdown; EZH2; Biology; Methyltransferase; Molecular biology; Histone methyltransferase; Epigenomics; Methylation; Downregulation and upregulation; Cancer research; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775595,0.0002066783,0.0002703951,0.0002640361,0.000170106,0.000255488,0.0001258133,0.0002881075,0.001558902],"category_scores_gemma":[0.0002075438,0.0001768868,0.0002492644,0.0001636434,0.0001789798,0.0001733394,0.0002975519,0.0004067346,0.000398184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021515,"about_ca_system_score_gemma":0.0002034825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008754327,"about_ca_topic_score_gemma":0.001164861,"domain_scores_codex":[0.9998968,0.00001830108,0.000008093591,0.00002424841,0.00002551542,0.00002711891],"domain_scores_gemma":[0.9998982,0.00001291764,0.00003561205,0.000009461874,0.00002244241,0.00002135079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004069157,0.00003480491,0.005902072,0.0001504939,0.00004007217,0.0002578505,0.00006624126,0.000136268,0.9793777,0.0005031888,0.0004754961,0.01264898],"study_design_scores_gemma":[0.0001547081,0.0005374511,0.2455559,0.00005589803,0.0002151214,0.002552661,0.0001919726,0.005100375,0.7120536,0.001429903,0.03211635,0.00003603394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683622,0.01996175,0.00655852,0.0006003515,0.00008079648,0.00004492089,0.0004951136,0.0002934478,0.00360294],"genre_scores_gemma":[0.9917698,0.003528058,0.001019701,0.00009991659,0.00002815244,0.00002811815,0.0003261494,0.000018844,0.003181293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001558902,"threshold_uncertainty_score":0.005215049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02634744859045154,"score_gpt":0.2705897749915075,"score_spread":0.2442423264010559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}