{"id":"W2437935337","doi":"10.1021/acs.bioconjchem.6b00240","title":"CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery","year":2016,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chemistry; Transfection; Hyaluronic acid; Gene delivery; CD44; Biophysics; Cytotoxicity; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002185933,0.0005850528,0.0004374272,0.0000759606,0.0001911752,0.00006311515,0.0006608371,0.0005341496,0.0001412965],"category_scores_gemma":[0.0002658736,0.0004697527,0.0003774811,0.0001493359,0.0002843124,0.00001513707,0.0002929255,0.0001262764,0.00008376683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021441,"about_ca_system_score_gemma":0.0003003313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001437383,"about_ca_topic_score_gemma":0.000005485938,"domain_scores_codex":[0.997137,0.00006256976,0.0005862949,0.001119911,0.0002638457,0.0008303758],"domain_scores_gemma":[0.9980727,0.0000679302,0.0002715792,0.0009158754,0.0004084787,0.0002633813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001373431,0.0001393265,0.0002347905,0.00008821911,0.000237841,0.00002260496,0.00003140437,0.00001064264,0.9915599,0.000002858735,0.004176971,0.002122034],"study_design_scores_gemma":[0.00236515,0.0004151219,0.0002346527,0.000107851,0.00007052172,0.00007028207,0.00009836362,0.0001056757,0.9755527,0.00002115815,0.02024704,0.0007114172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929492,0.00393075,0.0006049026,0.0003740205,0.0005029881,0.0005000478,0.000705803,0.00009272472,0.0003395716],"genre_scores_gemma":[0.9905332,0.0005784595,0.0003848101,0.0004228652,0.0006045693,0.0002163072,0.000694092,0.00009430917,0.006471375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01607007,"threshold_uncertainty_score":0.9997754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819561828115138,"score_gpt":0.2269449392398153,"score_spread":0.2171253774117001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}