{"id":"W2437935337","doi":"10.1021/acs.bioconjchem.6b00240","title":"CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery","year":2016,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Chemistry; Transfection; Hyaluronic acid; Gene delivery; CD44; Biophysics; Cytotoxicity; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220587,0.000273783,0.0001540481,0.0001824123,0.00008849579,0.000221654,0.0001543314,0.0002685663,0.0005565963],"category_scores_gemma":[0.0001311902,0.000163032,0.0002023167,0.000139495,0.0001210682,0.0002506502,0.0001686835,0.0003377277,0.0002299851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002600488,"about_ca_system_score_gemma":0.0001632417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003129462,"about_ca_topic_score_gemma":0.000534406,"domain_scores_codex":[0.9999126,0.00001271442,0.000008214241,0.00002243083,0.00003000375,0.0000139148],"domain_scores_gemma":[0.9999174,0.000008710141,0.00003332124,0.000005683537,0.00001901472,0.0000157667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001489964,0.00001057178,0.00005933767,0.00002310568,0.000003366854,0.00001192804,0.00000924703,0.0001086936,0.9983595,0.000083862,0.00002160316,0.001293863],"study_design_scores_gemma":[0.000006370534,0.00007215914,0.000531377,0.000002386623,0.00001000887,0.00006064466,0.000005607818,0.002554679,0.9955999,0.00002286215,0.001129339,0.000004683573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754118,0.002082243,0.02101867,0.00009231982,0.00003774822,0.00004576705,0.0001001257,0.0001694614,0.001041842],"genre_scores_gemma":[0.9824843,0.0006475589,0.01444527,0.00006046528,0.000009328743,0.00004358649,0.0001359633,0.00002859732,0.002144829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005565963,"threshold_uncertainty_score":0.001886845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819561828115138,"score_gpt":0.2269449392398153,"score_spread":0.2171253774117001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}