{"id":"W2438748188","doi":"10.18433/j3h03r","title":"Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Atomoxetine; Bupropion; Drug; Pharmacology; Drug metabolism; Medicine; Drug-drug interaction; Drug interaction; Methylphenidate; Psychiatry; Attention deficit hyperactivity disorder; Smoking cessation","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001403706,0.0006796272,0.0009557683,0.000185118,0.0004270902,0.000396798,0.000252703,0.0007340665,0.001750241],"category_scores_gemma":[0.002201283,0.000380195,0.0004252173,0.0001440309,0.0004466214,0.0003169837,0.0002842132,0.0004213394,0.0003752207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900627,"about_ca_system_score_gemma":0.000395582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007261854,"about_ca_topic_score_gemma":0.0009709478,"domain_scores_codex":[0.9988602,0.0005456944,0.0000543034,0.0001953574,0.0002622023,0.00008221384],"domain_scores_gemma":[0.9991448,0.000304099,0.0002292426,0.00007761869,0.00009315645,0.0001510551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2880643,0.009933405,0.2655709,0.001094459,0.001368457,0.002364266,0.000739364,0.0008747811,0.3333727,0.0002150978,0.0009915376,0.09541065],"study_design_scores_gemma":[0.005612074,0.2533884,0.7045472,0.0000250535,0.0008788058,0.002978143,0.0001791034,0.003464651,0.02704823,0.0001443526,0.001694287,0.00003970973],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977376,0.0007942657,0.0005907597,0.00002853712,0.00001900177,0.0003420402,0.00009834978,0.00002165502,0.0003676369],"genre_scores_gemma":[0.9980022,0.0002045532,0.0007325382,0.0001323779,0.00004007114,0.0001970649,0.000240828,0.000008185953,0.0004420388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750241,"threshold_uncertainty_score":0.00742358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1688210408199632,"score_gpt":0.4996675840237531,"score_spread":0.3308465432037899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}