{"id":"W2438929167","doi":"10.1089/aid.2004.20.1057","title":"Short Communication: Antiretroviral Protease Inhibitors Prevent L6 Muscle Cell Fusion by Reducing Calpain Activity","year":2004,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Myogenesis; Myogenin; Calpain; Myocyte; C2C12; Protease; Indinavir; Ritonavir; Biology; MyoD; Cell biology; Myosin; Molecular biology; Chemistry; Biochemistry; Immunology; Enzyme; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001867461,0.0004549853,0.0002877981,0.0001937637,0.0002122372,0.0003622786,0.0003950062,0.000592704,0.009991812],"category_scores_gemma":[0.0003332715,0.0000929423,0.0001742445,0.0001533138,0.0001538853,0.0002906404,0.000183125,0.0005980634,0.003448012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233665,"about_ca_system_score_gemma":0.0001123042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002741416,"about_ca_topic_score_gemma":0.0002979792,"domain_scores_codex":[0.9998382,0.0000368377,0.00002056689,0.0000236391,0.00005471329,0.00002592427],"domain_scores_gemma":[0.9997415,0.00008864915,0.00006278707,0.00002078562,0.00004562924,0.00004066298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001489974,0.00023906,0.0009963237,0.0006000575,0.00002544197,0.0003982997,0.00004105841,0.0000843859,0.9468086,0.0005209983,0.004617695,0.04417816],"study_design_scores_gemma":[0.0001036963,0.001192725,0.008271268,0.00002677427,0.00003227905,0.001640526,0.00003326574,0.0004907115,0.9547557,0.0001142027,0.03333291,0.000005905626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8445016,0.0918228,0.009679496,0.002778528,0.002191571,0.0001732742,0.002573257,0.0006624096,0.04561706],"genre_scores_gemma":[0.9032593,0.01832535,0.00869493,0.0009506835,0.001208757,0.00008777578,0.003666012,0.0001220679,0.06368513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009991812,"threshold_uncertainty_score":0.03342599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05979861091643295,"score_gpt":0.3870169653882862,"score_spread":0.3272183544718532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}