{"id":"W2439506215","doi":"10.1002/jcp.25459","title":"Pancreatic Endoderm‐Derived From Diabetic Patient‐Specific Induced Pluripotent Stem Cell Generates Glucose‐Responsive Insulin‐Secreting Cells","year":2016,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute for Genetic Engineering and Biotechnology","keywords":"Induced pluripotent stem cell; Biology; Stem cell; PDX1; Cell biology; Endoderm; Cellular differentiation; Enteroendocrine cell; Induced stem cells; Cell therapy; Insulin; Endocrinology; Internal medicine; Cancer research; Embryonic stem cell; Endocrine system; Medicine; Biochemistry; Islet; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002352466,0.0002874038,0.0002770133,0.0002965166,0.0001254809,0.0003920091,0.0002001472,0.0002665221,0.001688104],"category_scores_gemma":[0.000157804,0.0001122645,0.0002718009,0.0002817631,0.0001497236,0.0001447526,0.0003846936,0.0006929932,0.0007899815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396973,"about_ca_system_score_gemma":0.000273989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001686015,"about_ca_topic_score_gemma":0.0002974685,"domain_scores_codex":[0.999867,0.00001473246,0.00002218656,0.00003110705,0.00004985581,0.00001515311],"domain_scores_gemma":[0.9999391,0.00001122977,0.00001532032,0.000012024,0.00001047848,0.00001180163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007359532,0.00002872474,0.0006834841,0.0001626724,0.00001264,0.000384445,0.00004716852,0.0001541154,0.978249,0.0006421201,0.0005918265,0.01897031],"study_design_scores_gemma":[0.00004094033,0.0002442777,0.006339554,0.00003547986,0.0000697184,0.002357084,0.0000692986,0.001893415,0.9475386,0.0003646883,0.04103298,0.00001414544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.84468,0.019265,0.1039967,0.0009377882,0.0008927052,0.0006445324,0.007176105,0.00164968,0.02075743],"genre_scores_gemma":[0.9391071,0.008805001,0.03518695,0.0004674354,0.00008217592,0.0002104956,0.007194936,0.0001450394,0.008800892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688104,"threshold_uncertainty_score":0.005647242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486755288002317,"score_gpt":0.2059066564331509,"score_spread":0.1910391035531277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}