{"id":"W2441322017","doi":"10.1021/mp500770e","title":"A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer <b>FD18</b> Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft <i>in Vivo</i>","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; Research Grants Council, University Grants Committee","keywords":"Paclitaxel; Pharmacology; Doxorubicin; Daunorubicin; In vivo; P-glycoprotein; Multiple drug resistance; Chemistry; Vinblastine; Rhodamine 123; Anthracycline; Toxicity; Pharmacokinetics; Medicine; Chemotherapy; Cancer; Breast cancer; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004085055,0.000375016,0.0006685793,0.0003409935,0.00004302294,0.00001886844,0.0001908882,0.0002005932,0.00005287916],"category_scores_gemma":[0.00001838095,0.0003703791,0.0001332821,0.0006458758,0.0001608076,0.0001094515,0.00005528345,0.0004854289,0.000009355297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503928,"about_ca_system_score_gemma":0.0001738734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001208375,"about_ca_topic_score_gemma":0.0003825581,"domain_scores_codex":[0.9974867,0.0001027944,0.0007135576,0.0005423083,0.0006062321,0.0005484652],"domain_scores_gemma":[0.9986733,0.00002616094,0.0001826536,0.0004695049,0.000131108,0.0005172893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001022541,0.0004843054,0.008801192,0.0003330786,0.00008704646,0.001169736,0.001188572,0.0001526455,0.9835934,0.0006456303,0.001717721,0.0008041181],"study_design_scores_gemma":[0.02867243,0.0002188981,0.01581504,0.001368709,0.0004364036,0.0001003327,0.001140557,0.001349212,0.7975885,0.0009653363,0.1510957,0.00124884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807516,0.01006683,0.001847961,0.001031173,0.0003330426,0.001115387,0.0001247445,0.00008494595,0.004644271],"genre_scores_gemma":[0.9925102,0.0007653792,0.00435886,0.0004527861,0.00007180732,0.00001364937,0.00006288255,0.00008053111,0.001683886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1860049,"threshold_uncertainty_score":0.9998748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365772470854871,"score_gpt":0.2868221403428156,"score_spread":0.2631644156342668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}