{"id":"W2441322017","doi":"10.1021/mp500770e","title":"A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer <b>FD18</b> Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft <i>in Vivo</i>","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hong Kong Polytechnic University; Research Grants Council, University Grants Committee","keywords":"Paclitaxel; Pharmacology; Doxorubicin; Daunorubicin; In vivo; P-glycoprotein; Multiple drug resistance; Chemistry; Vinblastine; Rhodamine 123; Anthracycline; Toxicity; Pharmacokinetics; Medicine; Chemotherapy; Cancer; Breast cancer; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008657301,0.0002244746,0.0001557462,0.0001775023,0.0001065822,0.0001252483,0.00019735,0.0002746384,0.001192412],"category_scores_gemma":[0.00007208242,0.00006923213,0.0001356157,0.0001132156,0.0001132764,0.0001518434,0.00008532217,0.0004438821,0.0002930377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338302,"about_ca_system_score_gemma":0.0001421567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005964001,"about_ca_topic_score_gemma":0.0006284401,"domain_scores_codex":[0.9999667,0.000005573515,0.000002292393,0.0000109781,0.000007969871,0.000006452105],"domain_scores_gemma":[0.9999722,0.000002791379,0.000008285392,0.000002699211,0.000005177109,0.00000884472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002187083,0.00009888669,0.000199752,0.0000773798,0.000009586286,0.00009325414,0.00001880587,0.0001172506,0.9804327,0.0002043148,0.0008642589,0.01766503],"study_design_scores_gemma":[0.0003787577,0.002702391,0.005222565,0.00001490956,0.00003673206,0.002174636,0.00001656196,0.001048565,0.924378,0.0001318759,0.06387658,0.0000183792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957802,0.01531796,0.01828911,0.0005701262,0.00009132439,0.0002634065,0.001426122,0.000507888,0.005732029],"genre_scores_gemma":[0.9676774,0.004297999,0.01900187,0.000343814,0.00003945969,0.0001442195,0.002017541,0.00003800919,0.006439754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192412,"threshold_uncertainty_score":0.003989041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365772470854871,"score_gpt":0.2868221403428156,"score_spread":0.2631644156342668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}