{"id":"W2441712953","doi":"10.1021/acsmedchemlett.5b00171","title":"Identification of Bidentate Salicylic Acid Inhibitors of PTP1B","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; University of Toronto","funders":"Air Force Office of Scientific Research; Laboratory Directed Research and Development; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Instituto de Salud Carlos III; Seventh Framework Programme; Water Resources Research Institute, North Carolina State University; Directorate for Engineering; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; National Chung-Hsing University; Ministry of Science and Technology, Taiwan; University of Alberta; Ministerio de Educación, Cultura y Deporte; Canada Research Chairs; National Natural Science Foundation of China; National Research Foundation Singapore; Canada Foundation for Innovation; Dow Chemical Company; Canadian Institutes of Health Research; Central Taiwan University of Science and Technology; Government of Canada","keywords":"Chemistry; Salicylic acid; In vivo; Insulin resistance; Insulin; In vitro; Pharmacology; Biochemistry; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363417,0.000495901,0.0004464916,0.000268657,0.0001726603,0.0003685554,0.0005184922,0.000226285,0.001382326],"category_scores_gemma":[0.0001931747,0.0002099023,0.0003535758,0.0001834218,0.0001617858,0.0002471704,0.0003468323,0.0004166364,0.0003189496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004721851,"about_ca_system_score_gemma":0.0003071481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009137566,"about_ca_topic_score_gemma":0.001991237,"domain_scores_codex":[0.9998916,0.00001534015,0.000007780893,0.00002356653,0.00003410177,0.00002761967],"domain_scores_gemma":[0.999948,0.000006350187,0.00001655461,0.000005072621,0.000009125199,0.00001482985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001038367,0.0004597683,0.0008418822,0.0004375822,0.0001048112,0.0002318756,0.00005334074,0.01833286,0.9511176,0.003050612,0.0009151336,0.0234162],"study_design_scores_gemma":[0.0008639256,0.004477595,0.002158532,0.00004778073,0.0001831291,0.0005302494,0.00006534267,0.05618756,0.9177504,0.0008136735,0.01685227,0.00006953031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756911,0.004261397,0.01248546,0.0002468426,0.00005605466,0.0002334281,0.0005394025,0.0002472983,0.006238946],"genre_scores_gemma":[0.9861373,0.002328614,0.009336234,0.00006165665,0.00001158949,0.00008359888,0.0004842371,0.00003507205,0.001521777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382326,"threshold_uncertainty_score":0.004624307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137033896827713,"score_gpt":0.2530937605802677,"score_spread":0.2417234216119906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}