{"id":"W2441712953","doi":"10.1021/acsmedchemlett.5b00171","title":"Identification of Bidentate Salicylic Acid Inhibitors of PTP1B","year":2015,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; University of Toronto","funders":"Air Force Office of Scientific Research; Laboratory Directed Research and Development; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Instituto de Salud Carlos III; Seventh Framework Programme; Water Resources Research Institute, North Carolina State University; Directorate for Engineering; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; National Chung-Hsing University; Ministry of Science and Technology, Taiwan; University of Alberta; Ministerio de Educación, Cultura y Deporte; Canada Research Chairs; National Natural Science Foundation of China; National Research Foundation Singapore; Canada Foundation for Innovation; Dow Chemical Company; Canadian Institutes of Health Research; Central Taiwan University of Science and Technology; Government of Canada","keywords":"Chemistry; Salicylic acid; In vivo; Insulin resistance; Insulin; In vitro; Pharmacology; Biochemistry; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975669,0.0001359759,0.0001794289,0.00002570008,0.00001577674,0.000005359997,0.0002726351,0.00008575816,0.000008506521],"category_scores_gemma":[0.0003084012,0.000134535,0.00005987395,0.0001242175,0.0002526167,0.000006902596,0.0000930738,0.00007675434,0.00000384286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002154989,"about_ca_system_score_gemma":0.00007955163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005381076,"about_ca_topic_score_gemma":0.000001155341,"domain_scores_codex":[0.9988241,0.00002438901,0.0004233439,0.0002461215,0.0003178447,0.0001642577],"domain_scores_gemma":[0.9990103,0.000008480548,0.000327098,0.0004149249,0.0001283803,0.000110809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007976453,0.00002999504,0.001113515,0.00011247,0.00003614845,0.000004455125,0.0000606449,0.00001473472,0.9894114,0.000007506237,0.00877406,0.0003553638],"study_design_scores_gemma":[0.0005772154,0.00005312696,0.0002934357,0.00004475637,0.00003561671,0.00002220793,0.0001366239,0.000002886622,0.9978007,0.00002565676,0.0008919392,0.0001158059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995599,0.002914225,0.0004206713,0.0007061375,0.0001224153,0.0001030507,0.00004002701,0.00000912157,0.00008535675],"genre_scores_gemma":[0.998989,0.00004507529,0.0001273798,0.0002657252,0.0002682607,0.00001455038,0.0002228195,0.00001683239,0.0000503978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008389387,"threshold_uncertainty_score":0.5486177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137033896827713,"score_gpt":0.2530937605802677,"score_spread":0.2417234216119906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}